4.5 Review

Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease

Related references

Note: Only part of the references are listed.
Review Cell Biology

The role of inflammasome in Alzheimer's disease

Li Liu et al.

AGEING RESEARCH REVIEWS (2014)

Article Biochemistry & Molecular Biology

Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action

G. Elif Karagoz et al.

Article Dermatology

Increased expression of heat shock protein 90 in keratinocytes and mast cells in patients with psoriasis

Masato Kakeda et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2014)

Article Multidisciplinary Sciences

Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy

Julien Giustiniani et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Pharmacology & Pharmacy

Heat Shock Protein 70 Is Necessary to Improve Mitochondrial Bioenergetics and Reverse Diabetic Sensory Neuropathy following KU-32 Therapy

Jiacheng Ma et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)

Article Biochemistry & Molecular Biology

Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis

Chaitanya A. Patwardhan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Medicine, Research & Experimental

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau

Laura J. Blair et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Chemistry, Medicinal

Increasing the Efficiency of Ligands for FK506-Binding Protein 51 by Conformational Control

Yansong Wang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2

Pallav D. Patel et al.

NATURE CHEMICAL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle

Jing Li et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)

Review Geriatrics & Gerontology

Animal systems in the development of treatments for Alzheimer's disease: challenges, methods, and implications

Jonathan J. Sabbagh et al.

NEUROBIOLOGY OF AGING (2013)

Article Medicine, Research & Experimental

In silico design of small peptide-based Hsp90 inhibitor: A novel anticancer agent

Uday Kumar Gupta et al.

MEDICAL HYPOTHESES (2013)

Article Medicine, Research & Experimental

Design of novel Geldanamycin analogue hsp90 alpha-inhibitor in silico for breast cancer therapy

Sailendra Mahanta et al.

MEDICAL HYPOTHESES (2013)

Article Pharmacology & Pharmacy

A rat retinal damage model predicts for potential clinical visual disturbances induced by Hsp90 inhibitors

Dan Zhou et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)

Article Biochemistry & Molecular Biology

Structure, Function and Regulation of the Hsp90 Machinery

Johannes Buchner et al.

Biomedical Journal (2013)

Review Biochemistry & Molecular Biology

Hsp90 structure and function studied by NMR spectroscopy

Tatiana Didenko et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)

Article Biochemistry & Molecular Biology

Heat Shock Protein 90α (Hsp90α) Is Phosphorylated in Response to DNA Damage and Accumulates in Repair Foci

Maria Quanz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Cdc37/Hsp90 Protein Complex Disruption Triggers an Autophagic Clearance Cascade for TDP-43 Protein

Umesh K. Jinwal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Chemistry, Multidisciplinary

Development of a Grp94 inhibitor

Adam S. Duerfeldt et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Geriatrics & Gerontology

The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE

Rita J. Guerreiro et al.

NEUROBIOLOGY OF AGING (2012)

Article Multidisciplinary Sciences

Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects

Carmel T. Chan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Chemistry, Medicinal

Synthesis and evaluation of biotinylated sansalvamide A analogs and their modulation of Hsp90

Joseph B. Kunicki et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Article Biochemistry & Molecular Biology

The Hsp90 Kinase Co-chaperone Cdc37 Regulates Tau Stability and Phosphorylation Dynamics

Umesh K. Jinwal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Neurosciences

Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore

Sebastian A. Barrientos et al.

JOURNAL OF NEUROSCIENCE (2011)

Article Medicine, Research & Experimental

A Compound That Inhibits the HOP-Hsp90 Complex Formation and Has Unique Killing Effects in Breast Cancer Cell Lines

Genaro Pimienta et al.

MOLECULAR PHARMACEUTICS (2011)

Article Multidisciplinary Sciences

A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51

John C. O'Leary et al.

PLOS ONE (2011)

Article Multidisciplinary Sciences

Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells

Johanny Tonos De Leon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Pharmacology & Pharmacy

Withaferin A targets heat shock protein 90 in pancreatic cancer cells

Yanke Yu et al.

BIOCHEMICAL PHARMACOLOGY (2010)

Article Neurosciences

An okadaic acid-induced model of tauopathy and cognitive deficiency

Zhang Zhang et al.

BRAIN RESEARCH (2010)

Article Clinical Neurology

Tau in Alzheimer Disease and Related Tauopathies

K. Iqbal et al.

CURRENT ALZHEIMER RESEARCH (2010)

Review Chemistry, Medicinal

Proteasome Inhibitors: Recent Advances and New Perspectives In Medicinal Chemistry

E. Genin et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Celastrol Inhibits Hsp90 Chaperoning of Steroid Receptors by Inducing Fibrillization of the Co-chaperone p23

Ahmed Chadli et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Neurosciences

The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules

Umesh K. Jinwal et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Multidisciplinary Sciences

Differential Impact of Tetratricopeptide Repeat Proteins on the Steroid Hormone Receptors

Jan-Philip Schuelke et al.

PLOS ONE (2010)

Article Multidisciplinary Sciences

Analysis of Chaperone mRNA Expression in the Adult Mouse Brain by Meta Analysis of the Allen Brain Atlas

Andrew T. N. Tebbenkamp et al.

PLOS ONE (2010)

Article Multidisciplinary Sciences

A role for FKBP52 in Tau protein function

Beatrice Chambraud et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Chemistry, Medicinal

Mechanistic Studies of Sansalvamide A-Amide: An Allosteric Modulator of Hsp90

Robert C. Vasko et al.

ACS MEDICINAL CHEMISTRY LETTERS (2010)

Article Biochemistry & Molecular Biology

Modulation of Hsf1 activity by novobiocin and geldanamycin

Renaud Conde et al.

BIOCHEMISTRY AND CELL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Fluorescent Probes to Characterise FK506-Binding Proteins

Christian Kozany et al.

CHEMBIOCHEM (2009)

Article Neurosciences

The Cochaperone BAG2 Sweeps Paired Helical Filament-Insoluble Tau from the Microtubule

Daniel C. Carrettiero et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Neurosciences

Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability

Umesh K. Jinwal et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Multidisciplinary Sciences

The regulatory mechanism of Hsp90α secretion and its function in tumor malignancy

Xiaofeng Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Role of the cochaperone Tpr2 in Hsp90 chaperoning

Nela S. Cintron Moffatt et al.

BIOCHEMISTRY (2008)

Review Oncology

The Heat Shock Protein 90 Chaperone Complex: An Evolving Therapeutic Target

M. F. Barginear et al.

CURRENT CANCER DRUG TARGETS (2008)

Article Oncology

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

Tao Zhang et al.

MOLECULAR CANCER THERAPEUTICS (2008)

Article Biochemistry & Molecular Biology

Noncatalytic role of the FKBP52 peptidyl-prolyl isomerase domain in the regulation of steroid hormone signaling

Daniel L. Riggs et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Geriatrics & Gerontology

Inflammatory changes parallel the early stages of Alzheimer disease

A. Parachikova et al.

NEUROBIOLOGY OF AGING (2007)

Article Multidisciplinary Sciences

Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

Wenjie Luo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Chemistry, Medicinal

A non-toxic Hsp90 inhibitor protects neurons from Aβ-induced toxicity

Sabah Ansar et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

Article Medicine, Research & Experimental

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

Chad A. Dickey et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Article Biochemistry & Molecular Biology

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis

Xiaodong Wang et al.

Article Cell Biology

Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5

Alex von Kriegsheim et al.

NATURE CELL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

The human FK506-binding proteins: characterization of human FKBP19

SL Rulten et al.

MAMMALIAN GENOME (2006)

Article Biochemistry & Molecular Biology

The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins

SH McLaughlin et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

Article Chemistry, Medicinal

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90

HZ He et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

Article Cell Biology

BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP

V Arndt et al.

MOLECULAR BIOLOGY OF THE CELL (2005)

Article Biotechnology & Applied Microbiology

The HSP90 family of genes in the human genome: Insights into their divergence and evolution

B Chen et al.

GENOMICS (2005)

Article Biochemistry & Molecular Biology

In vivo evidence of CHIP up-regulation attenuating tau aggregation

N Sahara et al.

JOURNAL OF NEUROCHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Molecular basis for TPR domain-mediated regulation of protein phosphatase

J Yang et al.

EMBO JOURNAL (2005)

Article Biochemistry & Molecular Biology

Multiple domains of the co-chaperone Hop are important for Hsp70 binding

PE Carrigan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

L Petrucelli et al.

HUMAN MOLECULAR GENETICS (2004)

Article Biochemical Research Methods

Development of a fluorescence polarization assay for the molecular chaperone Hsp90

J Kim et al.

JOURNAL OF BIOMOLECULAR SCREENING (2004)

Article Biochemistry & Molecular Biology

Celastrols as inducers of the heat shock response and cytoprotection

SD Westerheide et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Chemistry, Medicinal

Synthesis of novel fluorescent probes for the molecular chaperone Hsp90

L Llauger-Bufi et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)

Article Biochemistry & Molecular Biology

Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system

A Brychzy et al.

EMBO JOURNAL (2003)

Article Biochemistry & Molecular Biology

Aha, another regulator for Hsp90 chaperones

MP Mayer et al.

MOLECULAR CELL (2002)

Article Biochemistry & Molecular Biology

Discovery of compounds that will prevent tau pathology

KS Kosik et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2002)

Article Biochemistry & Molecular Biology

The influence of ATP and p23 on the conformation of hsp90

WP Sullivan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Review Biochemistry & Molecular Biology

Heat-shock protein 90, a chaperone for folding and regulation

D Picard

CELLULAR AND MOLECULAR LIFE SCIENCES (2002)

Review Immunology

Roles of heat-shock proteins in antigen presentation and cross-presentation

ZH Li et al.

CURRENT OPINION IN IMMUNOLOGY (2002)

Review Geriatrics & Gerontology

Inflammation and Alzheimer's disease

H Akiyama et al.

NEUROBIOLOGY OF AGING (2000)