Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 17, Issue 7, Pages 839-855Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.2013.791679
Keywords
blood-testis-barrier; endocrine disrupting chemicals; spermatogenesis; steroidogenesis; testis; testis-specific proteins
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Funding
- National Institutes of Health [NICHD U54 HD029990, R01 HD056034]
- Hong Kong General Research Fund (GRF) [HKBU261812]
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Introduction: Exposure to endocrine disrupting chemicals (EDCs) has recently been linked to declining fertility in men in both developed and developing countries. Since many EDCs possess intrinsic estrogenic or androgenic activities, thus, the gonad is one of the major targets of EDCs. Areas covered: For the past 2 decades, studies found in the literature regarding the disruptive effects of these EDCs on reproductive function in human males and also rodents were mostly focused on oxidative stress-induced germ cell apoptosis, disruption of steroidogenesis, abnormal sperm production and disruption of spermatogenesis in particular cell adhesion function and the blood-testis-barrier (BTB) function. Herein, we highlight recent findings in the field illustrating testis-specific proteins are also targets of EDCs. Expert opinion: This information should be helpful in developing better therapeutic approach to manage ECD-induced reproductive toxicity. This information is also helpful to identify potential targets for male contraceptive development.
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