Related references
Note: Only part of the references are listed.Preclinical assessment of JNJ-26854165 (Serdemetan1), a novel tryptamine compound with radiosensitizing activity in vitro and in tumor xenografts
Cyrus Chargari et al.
CANCER LETTERS (2011)
Beyond effector caspase inhibition Bcl2L12 neutralizes p53 signaling in Glioblastoma
Alexander H. Stegh et al.
CELL CYCLE (2011)
Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein-Protein Interaction: Structure-Activity Studies Leading to Improved Potency
Ian R. Hardcastle et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
A Small-Molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis
Hongbo Wang et al.
MOLECULAR CANCER THERAPEUTICS (2011)
Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML
Bing Z. Carter et al.
BLOOD (2010)
Removing all obstacles A critical role for p53 in promoting tissue renewal
David W. Schoppy et al.
CELL CYCLE (2010)
The multiple levels of regulation by p53 ubiquitination
J. T. Lee et al.
CELL DEATH AND DIFFERENTIATION (2010)
INGN-225: a dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: observed association between immune response and enhanced chemotherapy effect
Alberto A. Chiappori et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2010)
Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor
Alexander H. Stegh et al.
GENES & DEVELOPMENT (2010)
Alternative cell death mechanisms in development and beyond
Junying Yuan et al.
GENES & DEVELOPMENT (2010)
Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX
Jason Phan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Identification and Characterization of the First Small Molecule Inhibitor of MDMX
Damon Reed et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53
Mark Demma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Clinical study of recombinant adenovirus-p53 combined with fractionated stereotactic radiotherapy for hepatocellular carcinoma
Zhi-xiang Yang et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2010)
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
Andrea Alimonti et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
The Novel Tryptamine Derivative JNJ-26854165 Induces Wild-Type p53-and E2F1-Mediated Apoptosis in Acute Myeloid and Lymphoid Leukemias
Kensuke Kojima et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Selective activation of p53-mediated tumour suppression in high-grade tumours
Melissa R. Junttila et al.
NATURE (2010)
Stage-specific sensitivity to p53 restoration during lung cancer progression
David M. Feldser et al.
NATURE (2010)
p53 isoforms gain functions
V. Olivares-Illana et al.
ONCOGENE (2010)
Pharmacological reactivation of mutant p53: from protein structure to the cancer patient
K. G. Wiman
ONCOGENE (2010)
Tamoxifen-induced apoptosis of rat C6 glioma cells via PI3K/Akt, JNK and ERK activation
Ying Feng et al.
ONCOLOGY REPORTS (2010)
The p53 orchestra: Mdm2 and Mdmx set the tone
Mark Wade et al.
TRENDS IN CELL BIOLOGY (2010)
p53 Regulation of Metabolic Pathways
Eyal Gottlieb et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
The Origins and Evolution of the p53 Family of Genes
Vladimir A. Belyi et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
Clinical Outcomes and Correlates of TP53 Mutations and Cancer
Ana I. Robles et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use
Magali Olivier et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
Transcriptional Regulation by p53
Rachel Beckerman et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
Multiple hepatic arterial injections of recombinant adenovirus p53 and 5-fluorouracil after transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma: a pilot phase II trial
Geng Tian et al.
ANTI-CANCER DRUGS (2009)
Functions of p53 in metabolism and invasion
Karen H. Vousden
BIOCHEMICAL SOCIETY TRANSACTIONS (2009)
Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis
Maria A. Lebedeva et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2009)
Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism
Paola Secchiero et al.
BLOOD (2009)
PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain
Jeremy M. R. Lambert et al.
CANCER CELL (2009)
Tumor Protein 53-Induced Nucear Protein 1 Is a Major Mediator of p53 Antioxidant Function
Carla E. Cano et al.
CANCER RESEARCH (2009)
Blinded by the Light: The Growing Complexity of p53
Karen H. Vousden et al.
CELL (2009)
In vitro and Clinical Studies of Gene Therapy with Recombinant Human Adenovirus-p53 Injection for Oral Leukoplakia
Yi Li et al.
CLINICAL CANCER RESEARCH (2009)
Biomarkers Predict p53 Gene Therapy Efficacy in Recurrent Squamous Cell Carcinoma of the Head and Neck
John Nemunaitis et al.
CLINICAL CANCER RESEARCH (2009)
MDM2 Antagonist Nutlin-3 Displays Antiproliferative and Proapoptotic Activity in Mantle Cell Lymphoma
Yoko Tabe et al.
CLINICAL CANCER RESEARCH (2009)
Induction of p53-Specific Immunity by a p53 Synthetic Long Peptide Vaccine in Patients Treated for Metastatic Colorectal Cancer
Frank M. Speetjens et al.
CLINICAL CANCER RESEARCH (2009)
Sister chromatid tension and the spindle assembly checkpoint
Luigi Nezi et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
Neural stem cells target intracranial glioma to deliver an oncolytic adenovirus in vivo
M. A. Tyler et al.
GENE THERAPY (2009)
Structural and Biochemical Studies of TIGAR (TP53-induced Glycolysis and Apoptosis Regulator)
Hua Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Reactive Oxygen Species-independent Oxidation of Thioredoxin in Hypoxia INACTIVATION OF RIBONUCLEOTIDE REDUCTASE AND REDOX-MEDIATED CHECKPOINT CONTROL
Harish Muniyappa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma
Lyndsay Davies et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)
Effect of Recombinant Adenovirus-p53 Combined With Radiotherapy on Long-Term Prognosis of Advanced Nasopharyngeal Carcinoma
Jian-ji Pan et al.
JOURNAL OF CLINICAL ONCOLOGY (2009)
Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response
Weimin Chen et al.
MOLECULAR CELL (2009)
Epidermal homeostasis: a balancing act of stem cells in the skin
Cedric Blanpain et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage
Ho-Chou Tu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
Surojit Sur et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Tumor Suppressive Functions of p53
Jack T. Zilfou et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
Sharad Kumar
NATURE REVIEWS CANCER (2009)
Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy
Sanjeev Shangary et al.
Annual Review of Pharmacology and Toxicology (2008)
Hematopoiesis: An evolving paradigm for stem cell biology
Stuart H. Orkin et al.
CELL (2008)
What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? - A role for Bcl2L12 as a multifunctional cell death regulator
Alexander H. Stegh et al.
CELL CYCLE (2008)
A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis
L. Weinmann et al.
CELL DEATH AND DIFFERENTIATION (2008)
Phase I study of adenovirus p53 administered by bronchoalveolar lavage in patients with bronchioloalveolar cell lung carcinoma: ECOG 6597
Vicki Keedy et al.
JOURNAL OF CLINICAL ONCOLOGY (2008)
Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer
Sanieev Shangary et al.
MOLECULAR CANCER THERAPEUTICS (2008)
P53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation
Keiko Kawauchi et al.
NATURE CELL BIOLOGY (2008)
The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2
J. Shen et al.
ONCOGENE (2008)
Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway
J. E. Kravchenko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma
Alexander H. Stegh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
Sanjeev Shangary et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Knockin mice expressing a Chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence
Thomas M. Johnson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
Frank M. Boeckler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Mesenchymal stem cells effectively deliver an oncolytic adenovirus to intracranial glioma
Adam M. Sonabend et al.
STEM CELLS (2008)
HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function
L. M. S. Lau et al.
ONCOGENE (2008)
Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia
Chris Saddler et al.
BLOOD (2008)
Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells
H. Ehrhardt et al.
ONCOGENE (2008)
Delayed ageing through damage protection by the Arf/p53 pathway
Ander Matheu et al.
NATURE (2007)
Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype:: Lessons from recent developments in the IARC TP53 database
Audrey Petitjean et al.
HUMAN MUTATION (2007)
A pivotal role for p53: balancing aerobic respiration and glycolysis
Wenzhe Ma et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2007)
p53 therapy in a patient with Li-Fraumeni syndrome
Neil Senzer et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1
G. Ambrosini et al.
ONCOGENE (2007)
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide
Federico Bernal et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Monoubiquitylation promotes mitochondrial p53 translocation
Natasha D. Marchenko et al.
EMBO JOURNAL (2007)
The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
Melissa Dumble et al.
BLOOD (2007)
Restoration of p53 function leads to tumour regression in vivo
Andrea Ventura et al.
NATURE (2007)
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Wen Xue et al.
NATURE (2007)
Novel recombinant adenoviral vector that targets the interleukin-13 receptor α2 chain permits effective gene transfer to malignant glioma
Ilya V. Ulasov et al.
HUMAN GENE THERAPY (2007)
Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma
Alexander H. Stegh et al.
GENES & DEVELOPMENT (2007)
p53 in health and disease
Karen H. Vousden et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Modeling the therapeutic efficacy of p53 restoration in tumors
Carla P. Martins et al.
CELL (2006)
MDMX overexpression prevents p53 activation by the MDM2 inhibitor nutlin
Baoli Hu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold
Ian R. Hardcastle et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
The p53 tumor suppressor participates in multiple cell cycle checkpoints
Luciana E. Giono et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2006)
A novel role for high-mobility group A proteins in cellular senescence and heterochromatin formation
Masashi Narita et al.
CELL (2006)
Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy
Yipin Lu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
p53 regulates mitochondrial respiration
Satoaki Matoba et al.
SCIENCE (2006)
Benzodiazepinedione inhibitors of the Hdm2 : p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo
HK Koblish et al.
MOLECULAR CANCER THERAPEUTICS (2006)
Divorcing ARF and p53: an unsettled case
Charles J. Sherr
NATURE REVIEWS CANCER (2006)
MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy
K Kojima et al.
BLOOD (2005)
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
JE Chipuk et al.
SCIENCE (2005)
Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs
VJN Bykov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint
G Rohaly et al.
CELL (2005)
PRIMA-1MET synergizes with cisplatin to induce tumor cell apoptosis
VJN Bykov et al.
ONCOGENE (2005)
Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction
H Yin et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
JIJ Leu et al.
NATURE CELL BIOLOGY (2004)
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD
AV Budanov et al.
SCIENCE (2004)
The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
F Schwartzenberg-Bar-Yoseph et al.
CANCER RESEARCH (2004)
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
JE Chipuk et al.
SCIENCE (2004)
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
LT Vassilev et al.
SCIENCE (2004)
Inhibition of p63 transcriptional activity by p14ARF:: Functional and physical link between human ARF tumor suppressor and a member of the p53 family
V Calabrò et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
LD Walensky et al.
SCIENCE (2004)
p21-mediated nuclear retention of cyclin B1-Cdk1 in response to genotoxic stress
FB Charrier-Savournin et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
A nonpeptidic sulfonamide inhibits the p53-mdm2 interaction and activates p53-dependent transcription in mdm2-overexpressing cells
PS Galatin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
p53 upregulates death receptor 4 expression through an intronic p53 binding site
XG Liu et al.
CANCER RESEARCH (2004)
Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity
CC O'Shea et al.
CANCER CELL (2004)
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
N Issaeva et al.
NATURE MEDICINE (2004)
A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting
EA Chiocca et al.
MOLECULAR THERAPY (2004)
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress
A Tinel et al.
SCIENCE (2004)
p53- and drug-induced apoptotic responses mediated by BH3-only proteins Puma and Noxa
A Villunger et al.
SCIENCE (2003)
Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription
JE Chipuk et al.
CANCER CELL (2003)
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
JR Jeffers et al.
CANCER CELL (2003)
Why did p53 gene therapy fail in ovarian cancer?
AG Zeimet et al.
LANCET ONCOLOGY (2003)
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
M Narita et al.
CELL (2003)
p53 activates ICAM-1 (CD54) expression in an NF-κB-independent manner
VG Gorgoulis et al.
EMBO JOURNAL (2003)
Regulatory approvals of pediatric oncology drugs: Previous experience and new initiatives
S Hirschfeld et al.
JOURNAL OF CLINICAL ONCOLOGY (2003)
p53 has a direct apoptogenic role at the mitochondria
M Mihara et al.
MOLECULAR CELL (2003)
The CD95(APO-1/Fas) DISC and beyond
ME Peter et al.
CELL DEATH AND DIFFERENTIATION (2003)
Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database
VJN Bykov et al.
CARCINOGENESIS (2002)
Cyclotherapy Protection of Normal Cells and Unshielding of Cancer Cells
Mikhail V. Blagosklonny et al.
CELL CYCLE (2002)
p53 mutant mice that display early ageing-associated phenotypes
SD Tyner et al.
NATURE (2002)
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
VJN Bykov et al.
NATURE MEDICINE (2002)
Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1
S North et al.
MOLECULAR CARCINOGENESIS (2002)
Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage
T Ando et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals
JW Han et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
PUMA induces the rapid apoptosis of colorectal cancer cells
J Yu et al.
MOLECULAR CELL (2001)
PUMA, a novel proapoptotic gene, is induced by p53
K Nakano et al.
MOLECULAR CELL (2001)
p21 Inhibits Thr161 phosphorylation of Cdc2 to enforce the G2 DNA damage checkpoint
VAJ Smits et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
FR Khuri et al.
NATURE MEDICINE (2000)
The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression
SQ Jin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Nora, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
E Oda et al.
SCIENCE (2000)
Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis
YP Lin et al.
NATURE GENETICS (2000)