Related references
Note: Only part of the references are listed.Development of FXR, PXR and CAR Agonists and Antagonists for Treatment of Liver Disorders
Stefano Fiorucci et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2012)
Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice
Shujuan Chen et al.
HEPATOLOGY (2012)
Organic Anion Transporting Polypeptide 1a1 Null Mice Are Sensitive to Cholestatic Liver Injury
Youcai Zhang et al.
TOXICOLOGICAL SCIENCES (2012)
Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene
Lucie Krausova et al.
BIOCHEMICAL PHARMACOLOGY (2011)
Rifampin Enhances the Glucose-Lowering Effect of Metformin and Increases OCT1 mRNA Levels in Healthy Participants
S. K. Cho et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
Polyinosinic-Polycytidylic Acid Suppresses Acetaminophen-Induced Hepatotoxicity Independent of Type I Interferons and Toll-Like Receptor 3
Amir A. Ghaffari et al.
HEPATOLOGY (2011)
Changes of Organic Anion Transporter MRP4 and Related Nuclear Receptors in Human Obstructive Cholestasis
Jin Chai et al.
JOURNAL OF GASTROINTESTINAL SURGERY (2011)
Enhanced steatosis by nuclear receptor ligands: A study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile
Marta Moya et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2010)
A Humanized UGT1 Mouse Model Expressing the UGT1A1*28 Allele for Assessing Drug Clearance by UGT1A1-Dependent Glucuronidation
Hongliang Cai et al.
DRUG METABOLISM AND DISPOSITION (2010)
A Role for the Pregnane X Receptor in Flucloxacillin-Induced Liver Injury
Elise Andrews et al.
HEPATOLOGY (2010)
The PXR is a drug target for chronic inflammatory liver disease
Karen Wallace et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2010)
The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury
Kun Wang et al.
LABORATORY INVESTIGATION (2010)
The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease
Silvia Sookoian et al.
PHARMACOGENETICS AND GENOMICS (2010)
Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity
Jie Cheng et al.
DRUG METABOLISM AND DISPOSITION (2009)
Clotrimazole Protects the Liver Against Normothermic Ischemia-Reperfusion Injury in Rats
A. Iannelli et al.
TRANSPLANTATION PROCEEDINGS (2009)
CYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized Liver
Tae Inoue et al.
DRUG METABOLISM AND DISPOSITION (2008)
Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis
S. Teng et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Effect of pregnane X receptor ligand on pharmacokinetics of substrates of organic cation transporter Oct1 in rats
Tomoji Maeda et al.
DRUG METABOLISM AND DISPOSITION (2007)
The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors
Marie-Louise Ricketts et al.
MOLECULAR ENDOCRINOLOGY (2007)
Rifampin is safe for treatment of pruritus due to chronic cholestasis: a meta-analysis of prospective randomized-controlled trials
Sandeep Khurana et al.
LIVER INTERNATIONAL (2006)
Mutual repression between steroid and xenobiotic receptor and NF-κB signaling pathways links xenobiotic metabolism and inflammation
Changcheng Zhou et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazoly/penicillin antibiotic flucloxacillin
J Huwyler et al.
CURRENT DRUG METABOLISM (2006)
Polymorphisms in the VKORC1 gene are strongly associated with warfarin dosage requirements in patients receiving anticoagulation
T. Li et al.
JOURNAL OF MEDICAL GENETICS (2006)
Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms
TL Noreault et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2005)
In vivo induction of human cytochrome P450 3A4 by rifabutin in chimeric mice with humanized liver
M Katoh et al.
XENOBIOTICA (2005)
Arsenite decreases CYP3A4 and RXRα in primary human hepatocytes
TL Noreault et al.
DRUG METABOLISM AND DISPOSITION (2005)
Pregnenolone-16α-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms
CJ Marek et al.
BIOCHEMICAL JOURNAL (2005)
Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites
J Sonoda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury
CAM Stedman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals
DS Riddick et al.
DRUG METABOLISM AND DISPOSITION (2004)
Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor
YP Chen et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Enhanced acetaminophen toxicity by activation of the pregnane X receptor
GL Guo et al.
TOXICOLOGICAL SCIENCES (2004)
Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor
J Sahi et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Role of the hepatocyte nuclear factor 4α in control of the pregnane X receptor during fetal liver development
A Kamiya et al.
HEPATOLOGY (2003)
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor
W Xie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
A nuclear receptor-mediated xenobiotic response and its implication in drug metabolism and host protection
J Sonoda et al.
CURRENT DRUG METABOLISM (2003)
Biological function and mode of action of nuclear xenobiotic receptors
J Sonoda et al.
PURE AND APPLIED CHEMISTRY (2003)
PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides
X Coumoul et al.
BIOCHEMICAL PHARMACOLOGY (2002)
Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR)
J Sonoda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification
JM Maglich et al.
MOLECULAR PHARMACOLOGY (2002)
Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response
AP Beigneux et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Regulation of multidrug resistance-associated protein 2 (ABCC2) by nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
HR Kast et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands
A Toell et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2002)
Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital
A Ueda et al.
MOLECULAR PHARMACOLOGY (2002)
Nuclear receptors and lipid physiology: Opening the X-files
A Chawla et al.
SCIENCE (2001)
Orphan nuclear receptors: The exotics of xenobiotics
W Xie et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription
A Takeshita et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2001)
The human nuclear xenobiotic receptor PXR: Structural determinants of directed promiscuity
RE Watkins et al.
SCIENCE (2001)
The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR
J Sugatani et al.
HEPATOLOGY (2001)
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
TW Synold et al.
NATURE MEDICINE (2001)
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
JL Staudinger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
W Xie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes
JM Pascussi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Humanized xenobiotic response in mice expressing nuclear receptor SXR
W Xie et al.
NATURE (2000)
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
LB Moore et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes
J Sahi et al.
XENOBIOTICA (2000)
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
JJ Repa et al.
SCIENCE (2000)
Share Paper
