Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 17, Issue 1, Pages 21-28Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.2012.732066
Keywords
angiogenesis; apoptosis; cell cycle; human cancers; hypoxia; microRNA; miR-210; survival
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Funding
- National Natural Scientific Foundation of China [81100714, 81171923, 30870636]
- Foundation of Shaanxi Province Science and Technology research [2012KJXX-20]
- Top PhD Foundation of China [201075]
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Introduction: As the predominant miRNA regulated by hypoxia, miR-210 correlates with survival in cancer patients. miR-210 may play important roles in regulation of cell growth, angiogenesis and apoptosis in different human tumor models, indicating that it can be used as a therapeutic target. Areas covered: This review covers all literature related to miR-210 in malignant tumors from the past 5 years, and analyzes the biological functions and molecular mechanisms of it. The authors also envisage future developments toward the clinical applications of miR-210 to cancer diagnosis and treatment. Expert opinion: miR-210 may function as a new therapeutic target for anticancer intervention. Considering that the exact function of miR-210 is still not well characterized and understood, more investigations should be performed to promote the success of therapeutic-clinical use of miR-210 in cancer.
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