4.5 Review

Targeting the Wnt/ββ-catenin signaling pathway in human cancers

Journal

EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 15, Issue 7, Pages 873-887

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.2011.577418

Keywords

cancer; cancer stem cell; high-throughput screening; Wnt; beta-catenin

Funding

  1. Ministry of Education, Culture, Sports, Science, and Technology of Japan
  2. Grants-in-Aid for Scientific Research [21390293, 23591404] Funding Source: KAKEN

Ask authors/readers for more resources

Areas covered: This review discusses the potential of inhibiting the Wnt/beta beta-catenin signaling pathway, as a therapeutic approach for cancer, along with an overview of the development of specific inhibitors. Expert opinion: Cancer stem cells (CSCs) play a significant role in the development and recurrence of several cancers, and Wnt/beta beta-catenin signaling is important for the proliferation of CSCs. Inhibition of Wnt/beta beta-catenin signaling is therefore a promising treatment approach. Progress has been made in the development of screening methods to identify Wnt/beta beta-catenin signaling inhibitors. Biomarker-based screening is an effective and promising method for the identification of compounds of interest.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available