Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 15, Issue 7, Pages 873-887Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.2011.577418
Keywords
cancer; cancer stem cell; high-throughput screening; Wnt; beta-catenin
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Grants-in-Aid for Scientific Research [21390293, 23591404] Funding Source: KAKEN
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Areas covered: This review discusses the potential of inhibiting the Wnt/beta beta-catenin signaling pathway, as a therapeutic approach for cancer, along with an overview of the development of specific inhibitors. Expert opinion: Cancer stem cells (CSCs) play a significant role in the development and recurrence of several cancers, and Wnt/beta beta-catenin signaling is important for the proliferation of CSCs. Inhibition of Wnt/beta beta-catenin signaling is therefore a promising treatment approach. Progress has been made in the development of screening methods to identify Wnt/beta beta-catenin signaling inhibitors. Biomarker-based screening is an effective and promising method for the identification of compounds of interest.
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