Related references
Note: Only part of the references are listed.A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo
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Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity
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Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy
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Effect of mutations in the PCSK9 gene on the cell surface LDL receptors
J Cameron et al.
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Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
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A spectrum of PCSK9 Alleles contributes to plasma levels of low-density lipoprotein cholesterol
IK Kotowski et al.
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Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote
Zhenze Zhao et al.
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No genetic association between PCSK9 polymorphisms and Alzheimer's disease and plasma cholesterol level in Japanese patients
N Shibata et al.
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Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene - Long-term follow-up and treatment response
RP Naoumova et al.
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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9
S Rashid et al.
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Proprotein convertase subtilisin kexin 9: the third locus implicated in autosomal dominant hypercholesterolemia
KN Maxwell et al.
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Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment
KN Maxwell et al.
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Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
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Proprotein convertase models based on the crystal structures of furin and kexin: Explanation of their specificity
S Henrich et al.
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Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia
TP Leren
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MR Arkin et al.
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A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree
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Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia
G Dubuc et al.
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Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver
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Intrabodies: Production and promise
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Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: An approach for inhibiting protein-protein interactions
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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype
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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
JD Horton et al.
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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
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Binding of small molecules to an adaptive protein-protein interface
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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1):: Liver regeneration and neuronal differentiation
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Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice
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Functional characterization of Narc 1, a novel proteinase related to proteinase K
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Structure of the LDL receptor extracellular domain at endosomal pH
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SCIENCE (2002)
Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction.: 4.: Structure-activity relationship of substituents on the benzene ring of the cinnamide
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