Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 14, Issue 1, Pages 45-55Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728220903431069
Keywords
apoptosis; cancer; carcinogenesis; chemoresistance; NF-kappa B; prevention; proliferation; therapy
Categories
Funding
- National Cancer Institute, NIH [R03CA125796]
- Department of Energy Low Dose Radiation Research Program [DE-FG02-09ER64783]
- NATIONAL CANCER INSTITUTE [R03CA125796] Funding Source: NIH RePORTER
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Importance of the field. Nuclear factor kappa B (NF-kappa B) is activated by a variety of cancer-promoting agents. The reciprocal activation between NF-kappa B and inflammatory cytokines makes NF-kappa B important for inflammation-associated cancer development. Both the constitutive and anticancer therapeutic-induced NF-kappa B activation blunts the anticancer activities of the therapy. Elucidating the roles of NF-kappa B in cancer facilitates developing approaches for cancer prevention and therapy. Areas covered in this review. By searching PubMed, we summarize the progress of studies on NF-kappa B in carcinogenesis and cancer cells' drug resistance in recent 10 years. What the reader will gain: The mechanisms by which NF-kappa B activation pathways are activated; the roles and mechanisms of NF-kappa B in cell survival and proliferation, and in carcinogenesis and cancer cells' response to therapy; recent development of NF-kappa B-modulating means and their application in cancer prevention and therapy. Take home message: NF-kappa B is involved in cancer development, modulating NF-kappa B activation pathways has important implications in cancer prevention and therapy. Due to the complexity of NF-kappa B roles in different cancers, careful evaluation of NF-kappa B's in each cancer type is crucial in this regard. More cancer cell-specific NF-kappa B inhibiting means are desired for improving anticancer efficacy and reducing systemic toxicity.
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