Journal
EXPERT OPINION ON THERAPEUTIC TARGETS
Volume 12, Issue 2, Pages 145-157Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.12.2.145
Keywords
alpha 1-antitrypsin; cystic fibrosis; elafin; elastase; neutrophil; secretory leukoprotease inhibitor
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Background: Cystic fibrosis (CF) is a lethal hereditary disease characterised by neutrophil-dominated lung inflammation. These abundant neutrophils produce neutrophil elastase (NE), a destructive serine protease that has direct actions on extracellular matrix proteins and has a role in the host response to inflammation and infection. Objective: This review examines the prospect of developing novel therapies for CF by targeting NE. The authors explore the functions of NE and of naturally-occurring and synthetic NE inhibitors. Methods: A literature search was conducted exploring the functions of NE and inhibitors of NE; naturally occurring and synthetic. Conclusions: Targeting NE in CF offers therapeutic potential, but optimal inhibitors that can be delivered safely and effectively to the lung are still under development.
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