Journal
EXPERT OPINION ON THERAPEUTIC PATENTS
Volume 22, Issue 12, Pages 1467-1477Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/13543776.2012.743994
Keywords
allosteric activator; AMP-activated protein kinase; AMPK direct activation; cancer; metabolic disorder
Categories
Ask authors/readers for more resources
Introduction: AMP-activated protein kinase (AMPK), a heterotrimeric protein complex with serine/threonine kinase activity has a central role in controlling cellular energy expenditure. Small molecule-based activation of AMPK represents an attractive therapeutic proposition because of AMPK's ability to regulate several anabolic and catabolic pathways that are critical to the development of metabolic disorders and cancer. Areas covered: A comprehensive review of published patents that disclose direct AMPK activators is provided: 26 patents comprising 10 chemical classes, and supporting in vitro and in vivo data are discussed. Expert opinion: AMPK activation holds promise as a possible pharmacological intervention in several disease states. The development of direct, highly specific AMPK activators is necessary to fully realize the opportunities linked to AMPK activation and appreciate the risks associated with it.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available