Aryl amide derivatives of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine derivatives useful as ASK1 inhibitors, an evaluation of WO2012080735

Novel 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine derivatives and their salts, compositions containing them and their use as ASK1 inhibitors in the treatment of inflammation and pain are claimed. The compounds have a broad potential utility with osteoarthritis and neuropathic pain among the likely preferred indications.