Related references
Note: Only part of the references are listed.Therapeutic Manipulation of the HIF Hydroxylases
Simon Nagel et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
Michele M. Hickey et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Erythropoiesis-Stimulating Agents - Time for a Reevaluation
Ellis F. Unger et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Erythropoietin and Tumor Angiogenesis
Domenico Ribatti
STEM CELLS AND DEVELOPMENT (2010)
Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology
Jennifer H. Dao et al.
ANALYTICAL BIOCHEMISTRY (2009)
Role of Oxygen in Cancer: Looking Beyond Hypoxia
Miguel Lopez-Lazaro
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2009)
Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
Massimiliano Mazzone et al.
CELL (2009)
Molecular mechanisms of pulmonary hypertension
Pinar Yidiz
CLINICA CHIMICA ACTA (2009)
Hypoxic Tumor Microenvironment and Cancer Cell Differentiation
Yuri Kim et al.
CURRENT MOLECULAR MEDICINE (2009)
HIF Prolyl 4-Hydroxylases and their Potential as Drug Targets
Johanna Myllyharju
CURRENT PHARMACEUTICAL DESIGN (2009)
HIF Prolyl-4-hydroxylase Interacting Proteins: Consequences for Drug Targeting
Roland H. Wenger et al.
CURRENT PHARMACEUTICAL DESIGN (2009)
Erythrocytosis-associated HIF-2α Mutations Demonstrate a Critical Role for Residues C-terminal to the Hydroxylacceptor Proline
Paul W. Furlow et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Role of Hypoxia in the Hallmarks of Human Cancer
Kai Ruan et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2009)
Application of a Proteolysis/Mass Spectrometry Method for Investigating the Effects of Inhibitors on Hydroxylase Structure
Christopher J. Stubbs et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Regulation of angiogenesis by oxygen sensing mechanisms
Guo-Hua Fong
JOURNAL OF MOLECULAR MEDICINE-JMM (2009)
Healthcare Expenditure and Resource Utilization in Patients with Anaemia and Chronic Kidney Disease: A Retrospective Claims Database Analysis
Jay Wish et al.
KIDNEY & BLOOD PRESSURE RESEARCH (2009)
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
Peter Fraisl et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Structure and Signaling Mechanism of Per-ARNT-Sim Domains
Andreas Moeglich et al.
STRUCTURE (2009)
Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases
Rasheduzzaman Chowdhury et al.
STRUCTURE (2009)
Characterization of a Robust Enzymatic Assay for Inhibitors of 2-Oxoglutarate-Dependent Hydroxylases
Kimon C. Kanelakis et al.
JOURNAL OF BIOMOLECULAR SCREENING (2009)
Biochemical Characterization of Human Prolyl Hydroxylase Domain Protein 2 Variants Associated with Erythrocytosis
Melissa B. Pappalardi et al.
BIOCHEMISTRY (2008)
Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors:: SAR, synthesis, and modeling evaluation
Christopher M. Tegley et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors
Mike Frohn et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Disturbance in the HIF-1α pathway associated with erythrocytosis:: Further evidences brought by frameshift and nonsense mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene
Maha Al-Sheikh et al.
BLOOD CELLS MOLECULES AND DISEASES (2008)
Genetic causes of erythrocytosis and the oxygen-sensing pathway
Frank S. Lee
BLOOD REVIEWS (2008)
Developments in the therapeutic use of erythropoiesis stimulating agents
Wolfgang Jelkmann
BRITISH JOURNAL OF HAEMATOLOGY (2008)
Role of the hypoxia inducible factors in iron metabolism
Carole Peyssonnaux et al.
CELL CYCLE (2008)
A novel heterozygous HIF2AM535I mutation reinforces the role of oxygen sensing pathway disturbances in the pathogenesis of familial erythrocytosis
Maurizio Martini et al.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2008)
Nuclear Oxygen Sensing: Induction of Endogenous Prolyl-hydroxylase 2 Activity by Hypoxia and Nitric Oxide
Utta Berchner-Pfannschmidt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The increase in pulmonary arterial pressure caused by hypoxia depends on iron status
Thomas G. Smith et al.
JOURNAL OF PHYSIOLOGY-LONDON (2008)
Gas phase reaction of substituted isoquinolines to carboxylic acids in ion trap and triple quadrupole mass spectrometers after electrospray ionization and collision-induced dissociation
Mario Thevis et al.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2008)
Expanding chemical biology of 2-oxoglutarate oxygenases
Christoph Loenarz et al.
NATURE CHEMICAL BIOLOGY (2008)
Brief Report: PHD2 Mutation and Congenital Erythrocytosis with Paraganglioma
Charline Ladroue et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
A gain-of-function mutation in the HIF2A gene in familial erythrocytosis
Melanie J. Percy et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor α
Peppi Koivunen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove
Melanie J. Percy et al.
BLOOD (2007)
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
Carole Peyssonnaux et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Emerging therapies for pulmonary arterial hypertension
Omar Ali et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2007)
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo
Erinn B. Rankin et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Acute postnatal ablation of Hif-2α results in anemia
Michaela Gruber et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
HIF-1α and EPAS ubiquitination mediated by the VHL tumour suppressor involves flexibility in the ubiquitination mechanism, similar to other RING E3 ligases
S. Paltoglou et al.
ONCOGENE (2007)
Pulmonary hypertension and erythropoietin
M. Buemi et al.
KIDNEY & BLOOD PRESSURE RESEARCH (2007)
Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay
Dominic Ehrismann et al.
BIOCHEMICAL JOURNAL (2007)
Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?
Abdullah Ozer et al.
NATURE CHEMICAL BIOLOGY (2007)
Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity
Eoin P. Cummins et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1α prolyl hydroxylase inhibitors
Namal C. Warshakoon et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors
Namal C. Warshakoon et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Design and synthesis of substituted pyridine derivatives as HIF-1α prolyl hydroxylase inhibitors
Namal C. Warshakoon et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Design and synthesis of a series of novel pyrazolopyridines as HIF 1-α prolyl hydroxylase inhibitors
Namal C. Warshakoon et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels -: Evidence for an autoregulatory oxygen-sensing system
Daniel P. Stiehl et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology
Thomas G. Smith et al.
PLOS MEDICINE (2006)
Cellular oxygen sensing:: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)
Michael A. McDonough et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins
Ian J. Clifton et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2006)
The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration?
E Beutler et al.
BLOOD (2006)
A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis
MJ Percy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Signalling hypoxia by HIF hydroxylases
CJ Schofield et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Possible role of erythropoietin in the pathogenesis of chronic cor pulmonale
A Allegra et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2005)
Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: A survival study
B Leyland-Jones et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
P Koivunen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress
K Salnikow et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1α-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases -: Substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for the proline leads to a high rate of uncoupled 2-oxoglutarate decarboxylation
DX Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Role of VHL gene mutation in human cancer
WY Kim et al.
JOURNAL OF CLINICAL ONCOLOGY (2004)
A nonradioactive 96-well plate assay for the detection of hypoxia-inducible factor prolyl hydroxylase activity
F Oehme et al.
ANALYTICAL BIOCHEMISTRY (2004)
Activation of HIF-1α at mRNA by hypoxia and iron chelator in isolated rat carotid body
A Roy et al.
NEUROSCIENCE LETTERS (2004)
Congenital disorder of oxygen sensing:: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors
VR Gordeuk et al.
BLOOD (2004)
Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy:: randomised, double-blind, placebo-controlled trial
M Henke et al.
LANCET (2003)
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
M Hirsilä et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
E Berra et al.
EMBO JOURNAL (2003)
Mutations of von Hippel-Lindau tumor-suppressor gene and congenital polycythemia
Y Pastore et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2003)
Regulation of angiogenesis by hypoxia: role of the HIF system
CW Pugh et al.
NATURE MEDICINE (2003)
Differential regulation of HIF-1α prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells
CL Cioffi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Intracellular localisation of human HIF-1α hydroxylases:: implications for oxygen sensing
E Metzen et al.
JOURNAL OF CELL SCIENCE (2003)
High-altitude pulmonary hypertension: a pathophysiological entity to different diseases
M Maggiorini et al.
EUROPEAN RESPIRATORY JOURNAL (2003)
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia
SO Ang et al.
NATURE GENETICS (2002)
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
M Ivan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors
F Oehme et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Structural basis for the recognition of hydroxyproline in αIF-1α by pVHL
WC Hon et al.
NATURE (2002)
Structure of an HIF-1α-pVHL complex:: Hydroxyproline recognition in signaling
JH Min et al.
SCIENCE (2002)
Desferrioxamine elevates pulmonary vascular resistance in humans: potential for involvement of HIF-1
GM Balanos et al.
JOURNAL OF APPLIED PHYSIOLOGY (2002)
Structural basis for Hif-1α/CBP recognition in the cellular hypoxic response
SA Dames et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
SJ Freedman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
D Lando et al.
SCIENCE (2002)
HIF-1 and tumor progression: pathophysiology and therapeutics
GL Semenza
TRENDS IN MOLECULAR MEDICINE (2002)
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α
DA Elson et al.
GENES & DEVELOPMENT (2001)
HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation
F Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Current concepts: High-altitude illness.
PH Hackett et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
HIFα targeted for VHL-mediated destruction by proline hydroxylation:: Implications for O2 sensing
M Ivan et al.
SCIENCE (2001)
Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
P Jaakkola et al.
SCIENCE (2001)
The von Hippel-Lindau tumor suppressor protein
M Ivan et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2001)
Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
T Kamura et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
ME Cockman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein
M Ohh et al.
NATURE CELL BIOLOGY (2000)
Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms
ME Massari et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)