4.2 Review

Treatment strategies for dystonia

Journal

EXPERT OPINION ON PHARMACOTHERAPY
Volume 11, Issue 1, Pages 5-15

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1517/14656560903426171

Keywords

anticholinergics; baclofen; benzodiazepines; dopaminergics; dystonia; tetrabenazine; therapeutics

Funding

  1. NCATS NIH HHS [U54 TR001456, UL1 TR000454] Funding Source: Medline
  2. NCRR NIH HHS [UL1 RR025008] Funding Source: Medline
  3. NINDS NIH HHS [U54 NS065701, R01 NS040470] Funding Source: Medline
  4. NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000454, U54TR001456] Funding Source: NIH RePORTER
  5. NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR025008] Funding Source: NIH RePORTER
  6. NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [U54NS065701, R01NS040470] Funding Source: NIH RePORTER

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Importance of the field: Dystonia is a neurological syndrome characterized by involuntary twisting movements and unnatural postures. it has many different manifestations and causes, and many different treatment options are available. These options include physical and occupational therapy, oral medications, intramuscular injection of botulinum toxins, and neurosurgical interventions. Areas covered in this review: in this review, we first summarize the treatment options available, then we provide suggestions from our own experience for how these can be applied in different types of dystonia. in preparing this review article, an extensive literature search was undertaken using PubMed. Only selected references from 1970 to 2008 are cited. What the reader will gain: This review is intended to provide the clinician with a practical guide to the treatment of dystonia. Take home message: Treatment of dystonia begins with proper diagnosis and classification, followed by an appropriate search for underlying etiology, and an assessment of the functional impairment associated with the dystonia. The therapeutic approach, which is usually limited to symptomatic therapy, must then be tailored to the individual needs of the patient.

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