Journal
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Volume 22, Issue 7, Pages 863-880Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/13543784.2013.794783
Keywords
antidepressants; antioxidant; monoaminergic neurotransmission; polyphenols
Categories
Ask authors/readers for more resources
Introduction: Natural polyphenols, the non-essential micronutrients, found in array of plant products, are known to affect various physiological and biochemical functions in the body. Studies have shown the protective effect of these polyphenols in different neurological and mental disorders. These polyphenols modulate monoaminergic neurotransmission in the brain and thus possess antidepressant-like activity at least in animal models of depression. Areas covered: The present review discusses the use of these natural polyphenols in the treatment of major depression. The review article discusses the antidepressant potential of some important polyphenols such as amentoflavone, apigenin, chlorogenic acid, curcumin, ferulic acid, hesperidin, rutin, quercetin, naringenin, resveratrol, ellagic acid, nobiletin and proanthocyanidins. The mechanism of action of these polyphenols in the treatment of major depression is also discussed in detail. Expert opinion: There is an exciting prospect in the discovery of natural polyphenols as therapeutic agents in the treatment of major depression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available