Pregabalin in clinical psychiatry and addiction: pros and cons

Pregabalin acts as a presynaptic modulator of excitatory neurotransmitter release, binding to the alpha(2)-delta subunit protein of voltage-gated calcium channels. Pregabalin use is becoming widespread in the psychiatric scenario. Data are encouraging, with some good evidence for efficacy in anxious spectrum, benzodiazepine abuse/dependence, and alcoholism. The abuse potential, however, is an issue that should be taken into account, mostly in subjects at risk for developing substance/alcohol misuse.