Related references
Note: Only part of the references are listed.SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis
Kapil Tahlan et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Sterilizing Activities of Novel Combinations Lacking First- and Second-Line Drugs in a Murine Model of Tuberculosis
Kathy Williams et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Phase II Dose-Ranging Trial of the Early Bactericidal Activity of PA-824
Andreas H. Diacon et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Randomized Pilot Trial of Eight Weeks of Bedaquiline (TMC207) Treatment for Multidrug-Resistant Tuberculosis: Long-Term Outcome, Tolerability, and Effect on Emergence of Drug Resistance
A. H. Diacon et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Linezolid: an effective, safe and cheap drug for patients failing multidrug-resistant tuberculosis treatment in India
R. Singla et al.
EUROPEAN RESPIRATORY JOURNAL (2012)
Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors
Marion Flipo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Delamanid for Multidrug-Resistant Pulmonary Tuberculosis
Maria Tarcela Gler et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
PA-824 Exhibits Time-Dependent Activity in a Murine Model of Tuberculosis
Zahoor Ahmad et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Characteristic Resistance Mechanism of Mycobacterium tuberculosis to DC-159a, a New Respiratory Quinolone
Jun-ichiro Sekiguchi et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Susceptibility of Clinical Mycobacterium tuberculosis Isolates to a Potentially Less Toxic Derivate of Linezolid, PNU-100480
J. W. C. Alffenaar et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
Activity of the Fluoroquinolone DC-159a in the Initial and Continuation Phases of Treatment of Murine Tuberculosis
Zahoor Ahmad et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2011)
WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update
D. Falzon et al.
EUROPEAN RESPIRATORY JOURNAL (2011)
Chemical modification of capuramycins to enhance antibacterial activity
Elena Bogatcheva et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2011)
Ethionamide Boosters: Synthesis, Biological Activity, and Structure-Activity Relationships of a Series of 1,2,4-Oxadiazole EthR Inhibitors
Marion Flipo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Sterilizing Activity of Second-Line Regimens Containing TMC207 in a Murine Model of Tuberculosis
Nicolas Veziris et al.
PLOS ONE (2011)
In Vitro Interactions between New Antitubercular Drug Candidates SQ109 and TMC207
Venkata M. Reddy et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Nervous System Effects of Antituberculosis Therapy
Joseph S. Kass et al.
CNS DRUGS (2010)
Antituberculosis drugs: Drug interactions, adverse effects, and use in special situations. Part 2: Second line drugs
Marcos Abdo Arbex et al.
JORNAL BRASILEIRO DE PNEUMOLOGIA (2010)
Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance
Giulia Manina et al.
MOLECULAR MICROBIOLOGY (2010)
Sterilizing Activity of R207910 (TMC207)-containing Regimens in the Murine Model of Tuberculosis
Murad Ibrahim et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)
Promising Antituberculosis Activity of the Oxazolidinone PNU-100480 Relative to That of Linezolid in a Murine Model
K. N. Williams et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Activity of SQ641, a Capuramycin Analog, in a Murine Model of Tuberculosis
Boris V. Nikonenko et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Synthetic EthR inhibitors boost antituberculous activity of ethionamide
Nicolas Willand et al.
NATURE MEDICINE (2009)
Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis
Vadim Makarov et al.
SCIENCE (2009)
Early and Extended Early Bactericidal Activity of Linezolid in Pulmonary Tuberculosis
Reynaldo Dietze et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2008)
Powerful bactericidal and sterilizing activity of a regimen containing PA-824, moxifloxacin, and pyrazinamide in a murine model of tuberculosis
Eric Nuermberger et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis
R. Rustomjee et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Case Series Report of a Linezolid-Containing Regimen for Extensively Drug-Resistant Tuberculosis*
Rany Condos et al.
CHEST (2008)
Fluoroquinolones: are they essential to treat multidrug resistant tuberculosis?
G. B. Migliori et al.
EUROPEAN RESPIRATORY JOURNAL (2008)
PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release
Ramandeep Singh et al.
SCIENCE (2008)
In vitro antimycobacterial activities of capuramycin analogues
Venkata M. Reddy et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Synergistic activity of R207910 combined with pyrazinamide against murine tuberculosis
M. Ibrahim et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice
Makoto Matsumoto et al.
PLOS MEDICINE (2006)
Combinations of R207910 with drugs used to treat multidrug-resistant tuberculosis have the potential to shorten treatment duration
Nacer Lounis et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Combination chemotherapy with the nitroimidazopyran PA-824 and first-line drugs in a murine model of tuberculosis
Eric Nuermberger et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Synergistic interactions of SQ109, a new ethylene diamine, with front-line antitubercular drugs in vitro
Ping Chen et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2006)
Efficacy and safety of linezolid in multidrug resistant tuberculosis (MDR-TB) - a report of ten cases
B von der Lippe et al.
JOURNAL OF INFECTION (2006)
Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: Functional analysis of mutant enzymes
A Aubry et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines
M Protopopova et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2005)
Pharmacoproteomic effects of isoniazid, ethambutol, and N-geranyl-N′-(2-adamantyl)ethane-1,2-diamine (SQ109) on Mycobacterium tuberculosis H37Rv
L Jia et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Molecular analysis of cross-resistance to capreomycin, kanamycin, arnikacin, and viomycin in Mycobacterium tuberculosis
CE Maus et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)
Activity of RBx 7644 and RBx 8700, new investigational oxazolidinones, against Mycobacterium tuberculosis infected murine macrophages
R Sood et al.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2005)
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
K Andries et al.
SCIENCE (2005)
EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator
J Engohang-Ndong et al.
MOLECULAR MICROBIOLOGY (2004)
Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis
F Frénois et al.
MOLECULAR CELL (2004)
Activity of capuramycin analogues against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellulare in vitro and in vivo
T Koga et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2004)
Discordant resistance to kanamycin and amikacin in drug-resistant Mycobacterium tuberculosis
A Krüüner et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2003)
Studies on novel bacterial translocase I inhibitors, A-500359s I. Taxonomy, fermentation, isolation, physico-chemical properties and structure elucidation of A-500359 A, C, D and G
Y Muramatsu et al.
JOURNAL OF ANTIBIOTICS (2003)
In vitro activities of linezolid against clinical isolates of Mycobacterium tuberculosis that are susceptible or resistant to first-line antituberculous drugs
L Alcala et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2003)
Structural mechanisms of QacR induction and multidrug recognition
MA Schumacher et al.
SCIENCE (2001)
The role of fluoroquinolones in tuberculosis today
SE Berning
DRUGS (2001)
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
CK Stover et al.
NATURE (2000)