4.5 Editorial Material

PLX4032: does it keep its promise for metastatic melanoma treatment?

Related references

Note: Only part of the references are listed.
Article Oncology

Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy

K. H. T. Paraiso et al.

BRITISH JOURNAL OF CANCER (2010)

Article Biochemistry & Molecular Biology

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

Sonja J. Heidorn et al.

Article Oncology

Targeting the Mitogen-Activated Protein Kinase Pathway: Physiological Feedback and Drug Response

Christine A. Pratilas et al.

CLINICAL CANCER RESEARCH (2010)

Editorial Material Medicine, Research & Experimental

Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032

Jill C. Rubinstein et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2010)

Article Medicine, Research & Experimental

Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032

Jonas N. Sondergaard et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2010)

Editorial Material Multidisciplinary Sciences

DRUG DISCOVERY Inhibitors that activate

Karen Cichowski et al.

NATURE (2010)

Article Multidisciplinary Sciences

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

Poulikos I. Poulikakos et al.

NATURE (2010)

Article Multidisciplinary Sciences

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Georgia Hatzivassiliou et al.

NATURE (2010)

Review Oncology

Genetic Subgrouping of Melanoma Reveals New Opportunities for Targeted Therapy

Keiran S. M. Smalley et al.

CANCER RESEARCH (2009)

Letter Oncology

Keratoacanthomas and Squamous Cell Carcinomas in Patients Receiving Sorafenib

Jean Philippe Arnault et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

Article Oncology

Final Version of 2009 AJCC Melanoma Staging and Classification

Charles M. Balch et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

Article Dermatology

Increasing Burden of Melanoma in the United States

Eleni Linos et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)

Editorial Material Oncology

Preclinical and clinical development of targeted therapy in melanoma: attention to schedule

Keith T. Flaherty et al.

PIGMENT CELL & MELANOMA RESEARCH (2009)

Article Multidisciplinary Sciences

MEK1 mutations confer resistance to MEK and B-RAF inhibition

Caroline M. Emery et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Oncology

Oncogene addiction

I. Bernard Weinstein et al.

CANCER RESEARCH (2008)

Article Dermatology

Short guidelines - Malignant melanoma of the skin

Claus Garbe et al.

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2008)

Article Chemistry, Medicinal

Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors

Savithri Ramurthy et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

Oncogenic BRAF Regulates Melanoma Proliferation through the Lineage Specific Factor MITF

Claudia Wellbrock et al.

PLOS ONE (2008)

Article Multidisciplinary Sciences

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

James Tsai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Cell Biology

Oncogene addiction: setting the stage for molecularly targeted cancer therapy

Sreenath V. Sharma et al.

GENES & DEVELOPMENT (2007)

Review Oncology

Management of metastatic melanoma

Hussein A. Tawbi et al.

SEMINARS IN ONCOLOGY (2007)

Review Pharmacology & Pharmacy

Selective Raf inhibition in cancer therapy

Vladimir Khazak et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2007)

Review Dermatology

Systemic therapy of disseminated malignant melanoma: an evidence-based overview of the state-of-the-art in daily routine

D. Nashan et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2007)

Article Multidisciplinary Sciences

BRAF mutation predicts sensitivity to MEK inhibition

DB Solit et al.

NATURE (2006)

Article Medicine, General & Internal

Distinct sets of genetic alterations in melanoma

JA Curtin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Pathology

Activation of the extracellular signal regulated kinase (ERK) pathway in human melanoma

L Zhuang et al.

JOURNAL OF CLINICAL PATHOLOGY (2005)

Article Biochemistry & Molecular Biology

The Ras/Raf/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma

F Meier et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2005)

Review Medicine, General & Internal

Medical progress - Management of cutaneous melanoma

H Tsao et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Article Multidisciplinary Sciences

Mutations of the BRAF gene in human cancer

H Davies et al.

NATURE (2002)

Article Surgery

UK guidelines for the management of cutaneous melanoma

JAN Bishop et al.

BRITISH JOURNAL OF PLASTIC SURGERY (2002)