Journal
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Volume 19, Issue 5, Pages 689-698Publisher
INFORMA HEALTHCARE
DOI: 10.1517/13543781003801076
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Funding
- NCI NIH HHS [R01 CA112112-01A1, R01 CA112112] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA112112] Funding Source: NIH RePORTER
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Areas covered in this review: Described in this review are the molecular targets of tipifarnib, safety and tolerability of the drug, chemistry, and clinical efficacy in AML. What the reader will gain: The reader will gain a thorough understanding of tipifarnib as it relates to the current and future use of the drug in AML. Take home message: The future of tipifarnib, along with other molecularly-targeted drugs, lies in achieving a better understanding of leukemia biology and harnessing the activity of this agent using predictive biomarkers for improved patient selection.
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