Related references
Note: Only part of the references are listed.Rapid and durable Antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection - Results of a 48-week controlled study
Martin Markowitz et al.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2007)
Metabolism and disposition in humans of raltegravir (MK-0518), an Anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme
Kelem Kassahun et al.
DRUG METABOLISM AND DISPOSITION (2007)
Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial
Beatriz Grinsztejn et al.
LANCET (2007)
Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals
Martin Markowitz et al.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2006)
A historical sketch of the discovery and development of HIV-1 integrase inhibitors
Andrea Savarino
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2006)
4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species
Vincenzo Summa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Integrase inhibitors to treat HIV/AIDS
Y Pommier et al.
NATURE REVIEWS DRUG DISCOVERY (2005)
Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques
DJ Hazuda et al.
SCIENCE (2004)
Metal-dependent inhibition of HIV-1 integrase by β-diketo acids and resistance of the soluble double-mutant (F185K/C280S)
C Marchand et al.
MOLECULAR PHARMACOLOGY (2003)
Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes
JA Grobler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
4-aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells
JS Wai et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
DJ Hazuda et al.
SCIENCE (2000)