Journal
EXPERT OPINION ON DRUG SAFETY
Volume 7, Issue 2, Pages 181-194Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14740338.7.2.181
Keywords
antidepressants; antipsychotics; arrhythmias; Brugada syndrome; long QT syndrome; sudden cardiac death
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Funding
- NHLBI NIH HHS [R01 HL047678, HL47678, R01 HL047678-15] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL047678, R55HL047678] Funding Source: NIH RePORTER
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A number of antipsychotic and antidepressant drugs are known to increase the risk of ventricular arrhythmias and sudden cardiac death. Based largely on a concern over QT prolongation and the development of life-threatening arrhythmias, a number of antipsychotic drugs have been temporarily or permanently withdrawn from the market or their use restricted. Some antidepressants and antipsychotics have been linked to QT prolongation and the development of Torsade de pointes arrhythmias, whereas others have been associated with a Brugada syndrome phenotype and the development of polymorphic ventricular arrhythmias. This review examines the mechanisms and predisposing factors underlying the development of cardiac arrhythmias, and sudden cardiac death, associated with antidepressant and antipsychotic drugs in clinical use.
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