Journal
EXPERT OPINION ON DRUG SAFETY
Volume 7, Issue 5, Pages 515-523Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14740338.7.5.515
Keywords
ceftriaxone; geriatrics; neonates; pediatrics; safety
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Background: Isolated reports of neonatal and infant deaths associated with ceftriaxone-calcium precipitation in the lungs and kidneys have prompted a recommendation from the US FDA in June 2007 advising that in patients of all ages, calcium-containing solutions should not be administered simultaneously or within 48 h of the last ceftriaxone dose. Objective: To provide a comprehensive review of the literature surrounding the safety of ceftriaxone in the neonatal (: 28 days) and geriatric populations (>= 65 years). Methods: Multi-database literature search for original research articles, review articles and case reports pertaining to safety of ceftriaxone in the neonatal and geriatric populations. Results/conclusions: Ceftriaxone should be avoided or significantly minimized in neonates (especially those treated concomitantly with intravenous calcium solutions and those with hyperbilirubinemia), and potentially restricted in the geriatric population treated concomitantly with intravenous calcium.
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