Journal
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
Volume 10, Issue 11, Pages 1509-1520Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425255.2014.963554
Keywords
5-hydroxytryptamine 1F receptor agonist; calcitonin gene-related peptide receptor antagonists; dopamine receptor antagonists; migraine attack therapy; N-methyl-D-aspartate receptor inhibitors; pituitary adenylate cyclase-activating polypeptide type 1 receptor
Funding
- Hungarian Brain Research Program (NAP) [KTIA_13_NAP-A-III/9]
- EUROHEADPAIN (FP7-Health-Innovation) [602633]
- MTA-SZTE Neuroscience Research Group of the Hungarian Academy of Sciences
- University of Szeged
- [TAMOP-4.2.2.A-11/1/KONV-2012-0052]
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Introduction: Migraine is a common, paroxysmal, and disabling primary headache with a high personal and socioeconomic impact. It involves similar to 16% of the general population. During the years, a number of hypotheses have been put forward concerning the exact pathomechanism, but the final solution is still undiscovered. Areas covered: Although the origin is enigmatic, parallel therapeutic efforts have been developed. Current attack therapy does not meet the expectations of the patients or the doctors. This article, based on a PubMed search, reviews the novel pharmacological possibilities that influence the peripheral and central sensitization involved in the disease. Expert opinion: In order to overcome the therapeutic insufficiency, a calcitonin gene-related peptide receptor antagonist without the side-effect of liver transaminase elevation is required. Another therapeutic option is to develop a neurally acting antimigraine agent, such as a serotonin-1F receptor agonist, with low adverse central nervous system events. Development of a potent dopamine receptor antagonist is necessary to diminish the premonitory symptoms of migraine. A further option is to decrease the headache intensity with a pituitary adenylate cyclase-activating polypeptide type 1 receptor blocker which can cross the blood-brain barrier. Finally, synthetic kynurenine analogues are required to block the pain transmission in the activated trigeminal system.
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