Journal
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
Volume 7, Issue 1, Pages 49-62Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425255.2011.538383
Keywords
ABCG2; LDL-C; pharmacogenetics; pharmacokinetics; polymorphisms; statins
Funding
- Research Grants Council of the Hong Kong Special Administrative Region, China [CUHK 4472/06 M]
- AstraZeneca
- Bayer
- Boehringer Ingelheim
- Daiichi Sankyo
- Kowa
- Merck
- Merck Sharp and Dohme
- Novartis
- Otsuka
- Pfizer
- Roche
- Sanofi-Aventis
- Servier
- School of Pharmacy
- Faculty of Medicine (CUHK)
Ask authors/readers for more resources
Areas covered in this review: We review and evaluate the associations of the ABCG2 polymorphism on the pharmacokinetics and clinical efficacy of statins. What the reader will gain: This article gives a detailed overview of the ABCG2 transporter and extensively reviews its relations with the pharmacokinetics and lipid-lowering effects of statins. This review also discusses the potential role of the ABCG2 polymorphism in the clinical outcomes in statin-treated patients and statin-drug interactions. Take home message: The impact of the ABCG2 421C > A polymorphism on the disposition of the statins varies between different drugs and the effect on systemic exposure was greater in the case of rosuvastatin than other statins. This genetic variant was associated with greater low-density lipoprotein cholesterol response to rosuvastatin in Chinese and caucasian patients. The effect of the ABCG2 421C > A polymorphism on the lipid response to other substrate statins and clinical outcomes need to be evaluated in future studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available