Related references
Note: Only part of the references are listed.Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4
Dmitri R. Davydov et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2008)
Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4
Abhinav Nath et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2008)
Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein
Harshica Fernando et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2008)
Multiple-ligand binding in CYP2A6: Probing mechanisms of cytochrome P450 cooperativity by assessing substrate dynarnics
John P. Harrelson et al.
BIOCHEMISTRY (2008)
Nile red is a fluorescent allosteric substrate of cytochrome P450 3A4
Jed N. Lampe et al.
BIOCHEMISTRY (2008)
Allosteric Transitions in Cytochrome P450eryF Explored with Pressure-Perturbation Spectroscopy, Lifetime FRET, and a Novel Fluorescent Substrate, Fluorol-7GA
Dmitri R. Davydov et al.
BIOCHEMISTRY (2008)
Cytochrome P450 and chemical toxicology
F. Peter Guengerich
CHEMICAL RESEARCH IN TOXICOLOGY (2008)
Comparative analysis of CYP3A heteroactivation by steroid hormones and flavonoids in different in vitro systems and potential in vivo implications
Jamie Henshall et al.
DRUG METABOLISM AND DISPOSITION (2008)
Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2 - Highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding
Christal D. Sohl et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Cooperative binding of acetaminophen and caffeine within the P450 3A4 active site
Michael D. Cameron et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2007)
Conformational dynamics of the cytochrome P450BM3/N-palmitoylglycine complex:: The proposed proximal-distal transition probed by temperature-jump spectroscopy
Sibylle Brenner et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2007)
Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: Pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket
Dmitri R. Davydov et al.
BIOCHEMISTRY (2007)
Cooperativity in cytochrome P450 3A4 -: Linkages in substrate binding, spin state, uncoupling, and product formation
Ilia G. Denisov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Mechanism of interactions of α-naphthoflavone with cytochrome p450 3A4 explored with an engineered enzyme bearing a fluorescent probe
Tamara N. Tsalkova et al.
BIOCHEMISTRY (2007)
Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W
Harshica Fernando et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)
Structure-function analysis of cytochrornes P4502B
Yonghong Zhao et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2007)
Time-resolved fluorescence studies of heterotropic ligand binding to cytochrome P450 3A4
Jed N. Lampe et al.
BIOCHEMISTRY (2006)
Structural basis for ligand promiscuity in cytochrome P450 3A4
Marika Ekroos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The ferrous-dioxygen intermediate in human cytochrome P450 3A4 - Substrate dependence of formation and decay kinetics
Ilia G. Denisov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Current views on the fundamental mechanisms of cytochrome P450 allosterism
William M. Atkins
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2006)
Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4
EM Isin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Resolution of multiple substrate binding sites in cytochrome P450 3A4: The stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration
H Fernando et al.
BIOCHEMISTRY (2006)
Active sites of two orthologous cytochromes P450 2E1: Differences revealed by spectroscopic methods
E Anzenbacherova et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: Heterogeneity of the enzyme caused by its oligomerization
DR Davydov et al.
BIOCHEMISTRY (2005)
Role of cytochrome B5 in modulating peroxide-supported CYP3A4 activity:: Evidence for a conformational transition and cytochrome P450 heterogeneity
S Kumar et al.
DRUG METABOLISM AND DISPOSITION (2005)
Resolution of two substrate-binding sites in an engineered cytochrome P450eryF bearing a fluorescent probe
DR Davydov et al.
BIOPHYSICAL JOURNAL (2005)
Predictive models of CYP3A4 heteroactivation: In vitro-in vivo scaling and pharmacophore modeling
AC Egnell et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Effects of ionic strength on the functional interactions between CYP2134 and CYP1A2
RW Kelley et al.
BIOCHEMISTRY (2005)
The thermodynamic landscape of testosterone binding to cytochrome P450 3A4: Ligand binding and spin state equilibria
AG Roberts et al.
BIOCHEMISTRY (2005)
Modelling atypical CYP3A4 kinetics: principles and pragmatism
JB Houston et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2005)
Structure of human microsomal cytochrome P4502C8 - Evidence for a peripheral fatty acid binding site
GA Schoch et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The structure of human cytochrome P4502C9 complexed with flurbiprofen at 2.0-Å resolution
MR Wester et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone
PA Williams et al.
SCIENCE (2004)
Implications of the allosteric kinetics of cytochrome P450s
WM Atkins
DRUG DISCOVERY TODAY (2004)
Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment
BJ Baas et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2004)
An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF
DR Davydov et al.
BIOCHEMISTRY (2004)
Allosterism in the elementary steps of the cytochrome P450 reaction cycle
MY Yoon et al.
DRUG METABOLISM REVIEWS (2004)
Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy
DR Davydov et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: Midazolam, testosterone, and nifedipine
A Galetin et al.
DRUG METABOLISM AND DISPOSITION (2003)
Fluorescence resonance energy transfer analysis of cytochromes P4502C2 and 2E1 molecular interactions in living cells
E Szczesna-Skorupa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Crystal structure of human cytochrome P4502C9 with bound warfarin
PA Williams et al.
NATURE (2003)
Organization of multiple cytochrome P450s with NADPH-cytochrome P450 reductase in membranes
WL Backes et al.
PHARMACOLOGY & THERAPEUTICS (2003)
Comparison of substrate metabolism by cytochromes P4502B1, 2B4, and 2B6:: relationship of heme spin state, catalysis, and the effects of cytochrome b5
JR Reed et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2003)
Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling
YA He et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2003)
Progress towards prediction of human pharmacokinetic parameters from in vitro technologies
JB Houston et al.
DRUG METABOLISM REVIEWS (2003)
Quinidine and haloperidol as modifiers of CYP3A4 activity: Multisite kinetic model approach
A Galetin et al.
DRUG METABOLISM AND DISPOSITION (2002)
Pyrene-pyrene complexes at the active site of cytochrome P450 3A4: Evidence for a multiple substrate binding site
MJ Dabrowski et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Allosteric mechanisms in P450eryF probed with 1-pyrenebutanol, a novel fluorescent substrate
DR Davydov et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Allosteric phenomena in cytochrome P450-catalyzed monooxygenations
P Hlavica et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)
Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity
TL Domanski et al.
BIOCHEMISTRY (2001)
Covalent alteration of the CYP3A4 active site: Evidence for multiple substrate binding domains
ML Schrag et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2001)
Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions
W Tang et al.
CURRENT DRUG METABOLISM (2001)
Allosteric behavior in cytochrome P450-dependent in vitro drug-drug interactions: A prospective based on conformational dynamics
WM Atkins et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2001)
A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4
M Shou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Stabilization of P4502B4 by its association with P450 1A2 revealed by high-pressure spectroscopy
DR Davydov et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Elucidation of distinct ligand binding sites for cytochrome P450 3A4
NA Hosea et al.
BIOCHEMISTRY (2000)
The catalytic pathway of cytochrome P450cam at atomic resolution
I Schlichting et al.
SCIENCE (2000)
Share Paper
