Journal
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
Volume 5, Issue 1, Pages 29-37Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425250802661895
Keywords
adverse drug reactions; genomics; proteomics; toxicity
Ask authors/readers for more resources
Background: In the toxicology field, it remains a major challenge to predict and understand drug toxicity and adverse drug reactions (ADRs) in man. Objective: Recent progress in genomics and proteomics technologies and their application in predicting drug toxicity and ADRs. Methods: The key genomic and proteomic approaches are outlined, their applications in predicting toxicity and ADRs are described and their future developments in this field are discussed. Conclusion: These technologies, used to measure expression at the transcript and protein levels, each convey different information and have different technical capabilities that can complement each other. The fields of genomics and proteomics continue to develop rapidly and it is already evident that genomic and proteomic approaches have much to contribute to the early prediction of drug toxicity and ADRs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available