Related references
Note: Only part of the references are listed.Modulating Self-Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms
Tingyu Liu et al.
CHEMMEDCHEM (2012)
Interaction of Thioflavin T with Amyloid Fibrils: Fluorescence Quantum Yield of Bound Dye
Anna I. Sulatskaya et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2012)
Is there a biological cost of protein disorder? Analysis of cancer-associated mutations
Matyas Pajkos et al.
MOLECULAR BIOSYSTEMS (2012)
A Novel Molecular Tweezer Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo
Shubhangi Prabhudesai et al.
NEUROTHERAPEUTICS (2012)
Analyzing Thioflavin T Binding to Amyloid Fibrils by an Equilibrium Microdialysis-Based Technique
Irina M. Kuznetsova et al.
PLOS ONE (2012)
Hydrophobic, Aromatic, and Electrostatic Interactions Play a Central Role in Amyloid Fibril Formation and Stability
Karen E. Marshall et al.
BIOCHEMISTRY (2011)
Intrinsically disordered proteins may escape unwanted interactions via functional misfolding
Vladimir N. Uversky
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2011)
Protein kinase biochemistry and drug discovery
Phillip A. Schwartz et al.
BIOORGANIC CHEMISTRY (2011)
Flexible Nets of Malleable Guardians: Intrinsically Disordered Chaperones in Neurodegenerative Diseases
Vladimir N. Uversky
CHEMICAL REVIEWS (2011)
Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes
Vladimir N. Uversky
CHEMICAL SOCIETY REVIEWS (2011)
Interaction of Thioflavin T with Amyloid Fibrils: Stoichiometry and Affinity of Dye Binding, Absorption Spectra of Bound Dye
Anna I. Sulatskaya et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2011)
Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins
Sharmistha Sinha et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Understanding protein non-folding
Vladimir N. Uversky et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)
Archaic chaos: intrinsically disordered proteins in Archaea
Bin Xue et al.
BMC SYSTEMS BIOLOGY (2010)
Intrinsically disordered proteins are potential drug targets
Steven J. Metallo
CURRENT OPINION IN CHEMICAL BIOLOGY (2010)
Drugs for 'protein clouds': targeting intrinsically disordered transcription factors
A. Keith Dunker et al.
CURRENT OPINION IN PHARMACOLOGY (2010)
Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D2 concept
Vladimir N. Uversky
EXPERT REVIEW OF PROTEOMICS (2010)
Mysterious oligomerization of the amyloidogenic proteins
Vladimir N. Uversky
FEBS JOURNAL (2010)
Seeded Aggregation and Toxicity of α-Synuclein and Tau CELLULAR MODELS OF NEURODEGENERATIVE DISEASES
Takashi Nonaka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The Mysterious Unfoldome: Structureless, Underappreciated, Yet Vital Part of Any Given Proteome
Vladimir N. Uversky
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2010)
Characterization of Inhibitor-Bound α-Synuclein Dimer: Role of α-Synuclein N-Terminal Region in Dimerization and Inhibitor Binding
Yoshiki Yamaguchi et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
The (un)targeted cancer kinome
Oleg Fedorov et al.
NATURE CHEMICAL BIOLOGY (2010)
Membrane transporters in drug development
Kathleen M. Giacomini et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
The protein kingdom extended: Ordered and intrinsically disordered proteins, their folding, supramolecular complex formation, and aggregation
Konstantin K. Turoverov et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2010)
ANCHOR: web server for predicting protein binding regions in disordered proteins
Zsuzsanna Dosztanyi et al.
BIOINFORMATICS (2009)
Unfoldomics of human diseases: linking protein intrinsic disorder with diseases
Vladimir N. Uversky et al.
BMC GENOMICS (2009)
Predicting intrinsic disorder in proteins: an overview
Bo He et al.
CELL RESEARCH (2009)
Biophysics of Parkinson's Disease: Structure and Aggregation of alpha-Synuclein
Vladimir N. Uversky et al.
CURRENT PROTEIN & PEPTIDE SCIENCE (2009)
Structural disorder in amyloid fibrils: its implication in dynamic interactions of proteins
P. Tompa
FEBS JOURNAL (2009)
Intrinsic disorder in proteins associated with neurodegenerative diseases
Vladimir N. Uversky
FRONTIERS IN BIOSCIENCE-LANDMARK (2009)
Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc
Dalia I. Hammoudeh et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism
Ashwani K. Thakur et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Unfoldomics of Human Genetic Diseases: Illustrative Examples of Ordered and Intrinsically Disordered Members of the Human Diseasome
Uros Midic et al.
PROTEIN AND PEPTIDE LETTERS (2009)
Do viral proteins possess unique biophysical features?
Nobuhiko Tokuriki et al.
TRENDS IN BIOCHEMICAL SCIENCES (2009)
Prediction of Protein Binding Regions in Disordered Proteins
Balint Meszaros et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
Intrinsically disordered proteins in human diseases: Introducing the D-2 concept
Vladimir N. Uversky et al.
ANNUAL REVIEW OF BIOPHYSICS (2008)
The unfoldomics decade: an update on intrinsically disordered proteins
A. Keith Dunker et al.
BMC GENOMICS (2008)
Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners
Christopher J. Oldfield et al.
BMC GENOMICS (2008)
Function and structure of inherently disordered proteins
A. Keith Dunker et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2008)
Ion channels as drug targets: The next GPCRs
Gregory J. Kaczorowski et al.
JOURNAL OF GENERAL PHYSIOLOGY (2008)
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
Dagmar E. Ehrnhoefer et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Fuzzy complexes: polymorphism and structural disorder in protein-protein interactions
Peter Tompa et al.
TRENDS IN BIOCHEMICAL SCIENCES (2008)
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
James A. Wells et al.
NATURE (2007)
Improved low molecular weight Myc-Max inhibitors
Huabo Wang et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Composition Profiler: a tool for discovery and visualization of amino acid composition differences
Vladimir Vacic et al.
BMC BIOINFORMATICS (2007)
Local structural disorder imparts plasticity on linear motifs
Monika Fuxreiter et al.
BIOINFORMATICS (2007)
Predicting protein disorder and induced folding: From theoretical principles to practical applications
Jean M. Bourhis et al.
CURRENT PROTEIN & PEPTIDE SCIENCE (2007)
Prediction of protein disorder at the domain level
Zsuzsanna Dosztanyi et al.
CURRENT PROTEIN & PEPTIDE SCIENCE (2007)
Role of intrinsic disorder in transient interactions of hub proteins
Gajinder Pal Singh et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2007)
Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions
Hongbo Xie et al.
JOURNAL OF PROTEOME RESEARCH (2007)
Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins
Hongbo Xie et al.
JOURNAL OF PROTEOME RESEARCH (2007)
Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions
Slobodan Vucetic et al.
JOURNAL OF PROTEOME RESEARCH (2007)
Intrinsic disorder and functional proteomics
Predrag Radivojac et al.
BIOPHYSICAL JOURNAL (2007)
Disorder and sequence repeats in hub proteins and their implications for network evolution
Zsuzsanna Dosztanyi et al.
JOURNAL OF PROTEOME RESEARCH (2006)
Opinion - Drugs, their targets and the nature and number of drug targets
Peter Imming et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
A practical overview of protein disorder prediction methods
Francois Ferron et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2006)
Honing the in silico toolkit for detecting protein disorder
Robert M. Esnouf et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2006)
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes
Chad Haynes et al.
PLOS COMPUTATIONAL BIOLOGY (2006)
Small molecule inhibitors of α-synuclein filament assembly
Masami Masuda et al.
BIOCHEMISTRY (2006)
Disordered domains and high surface charge confer hubs with the ability to interact with multiple proteins in interaction networks
A Patil et al.
FEBS LETTERS (2006)
What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae?
Diana Ekman et al.
GENOME BIOLOGY (2006)
A molecular tweezer for lysine and arginine
M Fokkens et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Flexible nets - The roles of intrinsic disorder in protein interaction networks
AK Dunker et al.
FEBS JOURNAL (2005)
Coupled folding and binding with α-helix-forming molecular recognition elements
CJ Oldfield et al.
BIOCHEMISTRY (2005)
The interplay between structure and function in intrinsically unstructured proteins
P Tompa
FEBS LETTERS (2005)
Intrinsically unstructured proteins and their functions
HJ Dyson et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Comparing and combining predictors of mostly disordered proteins
CJ Oldfield et al.
BIOCHEMISTRY (2005)
Natively unfolded proteins
AL Fink
CURRENT OPINION IN STRUCTURAL BIOLOGY (2005)
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling
VN Uversky et al.
JOURNAL OF MOLECULAR RECOGNITION (2005)
Strategies for targeting protein-protein interactions with synthetic agents
H Yin et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Prediction and functional analysis of native disorder in proteins from the three kingdoms of life
JJ Ward et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
LT Vassilev et al.
SCIENCE (2004)
Biochemical mechanisms of drug action: what does it take for success?
DC Swinney
NATURE REVIEWS DRUG DISCOVERY (2004)
The role of structural disorder in the function of RNA and protein chaperones
P Tompa et al.
FASEB JOURNAL (2004)
Principles for modulation of the nuclear receptor superfamily
H Gronemeyer et al.
NATURE REVIEWS DRUG DISCOVERY (2004)
Preformed structural elements feature in partner recognition by intrinsically unstructured proteins
M Fuxreiter et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy
WL Shao et al.
BREAST CANCER RESEARCH (2004)
Low molecular weight inhibitors of Myc-Max interaction and function
XY Yin et al.
ONCOGENE (2003)
Protein folding revisited. A polypeptide chain at the folding-misfolding-nonfolding cross-roads: which way to go?
VN Uversky
CELLULAR AND MOLECULAR LIFE SCIENCES (2003)
Orphan nuclear receptor modulators
R Mohan et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2003)
Intrinsic disorder in cell-signaling and cancer-associated proteins
LM Iakoucheva et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
Intrinsically unstructured proteins
P Tompa
TRENDS IN BIOCHEMICAL SCIENCES (2002)
The druggable genome
AL Hopkins et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
Live or let die: The cell's response to p53
KH Vousden et al.
NATURE REVIEWS CANCER (2002)
Intrinsic disorder and protein function
AK Dunker et al.
BIOCHEMISTRY (2002)
Natively unfolded proteins: A point where biology waits for physics
VN Uversky
PROTEIN SCIENCE (2002)
What does it mean to be natively unfolded?
VN Uversky
EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)
Activation and activities of the p53 tumour suppressor protein
É Bálint et al.
BRITISH JOURNAL OF CANCER (2001)
Intrinsically disordered protein
AK Dunker et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2001)
Local structural elements in the mostly unstructured transcriptional activation domain of human p53
H Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Protein-protein interactions in receptor activation and intracellular signalling
TL Blundell et al.
BIOLOGICAL CHEMISTRY (2000)
A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines
P Chène et al.
JOURNAL OF MOLECULAR BIOLOGY (2000)