4.5 Review

Heterodimerisation of G protein-coupled receptors: implications for drug design and ligand screening

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Recent advances in bioluminescence resonance energy transfer technologies to study GPCR heteromerization

Mohammed A. Ayoub et al.

CURRENT OPINION IN PHARMACOLOGY (2010)

Review Biochemistry & Molecular Biology

Diversity in arrestin function

Ryan T. Kendall et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2009)

Review Cell Biology

Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways

Jeffrey J. Kovacs et al.

DEVELOPMENTAL CELL (2009)

Article Biochemistry & Molecular Biology

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

Yang Han et al.

NATURE CHEMICAL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Building a new conceptual framework for receptor heteromers

Sergi Ferre et al.

NATURE CHEMICAL BIOLOGY (2009)

Article Pharmacology & Pharmacy

Mu-opioid receptor beterooligomer formation with the dopamine D1 receptor as directly visualized in living cells

Jason R. Juhasz et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

Article Endocrinology & Metabolism

G Protein Coupled Receptors as Drug Targets: The Role of β-Arrestins

Jasmin Dromey et al.

Endocrine Metabolic & Immune Disorders-Drug Targets (2008)

Review Pharmacology & Pharmacy

Novel pharmacological applications of G-protein-coupled receptor-G protein fusions

Graeme Milligan et al.

CURRENT OPINION IN PHARMACOLOGY (2007)

Article Biochemistry & Molecular Biology

Monitoring interactions between G-protein-coupled receptors and β-arrestins

K. D. G. Pfleger et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2007)

Article Biochemical Research Methods

Using ligand-induced conformational change to screen for compounds targeting G-protein-coupled receptors

Brian F. O'Dowd et al.

JOURNAL OF BIOMOLECULAR SCREENING (2007)

Article Pharmacology & Pharmacy

Functional selectivity and classical concepts of quantitative pharmacology

Jonathan D. Urban et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)

Article Pharmacology & Pharmacy

The G12 family of G proteins as a reporter of thromboxane A2 receptor activity

L Zhang et al.

MOLECULAR PHARMACOLOGY (2006)

Article Pharmacology & Pharmacy

Bring your own G protein

JD Hildebrandt

MOLECULAR PHARMACOLOGY (2006)

Article Pharmacology & Pharmacy

Interactions between the Mas-related receptors MrgD and MrgE alter signalling and trafficking of MrgD

S Milasta et al.

MOLECULAR PHARMACOLOGY (2006)

Article Biochemical Research Methods

Bioluminescence resonance energy transfer (BRET) for the real-time detection of protein-protein interactions

Kevin D. G. Pfleger et al.

NATURE PROTOCOLS (2006)

Review Pharmacology & Pharmacy

The structural basis of arrestin-mediated regulation of G-protein-coupled receptors

Vsevolod V. Gurevich et al.

PHARMACOLOGY & THERAPEUTICS (2006)

Article Biochemistry & Molecular Biology

Structural basis of antigen mimicry in a clinically relevant melanoma antigen system

CC Chung et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

Crosstalk in G protein-coupled receptors: Changes at the transmembrane homodimer interface determine activation

W Guo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Dopamine receptor oligomerization visualized in living cells

BF O'Dowd et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities

S Wilson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemical Research Methods

Evaluation of the InteraX™ System technology in a high-throughput screening environment

FH Büttner et al.

JOURNAL OF BIOMOLECULAR SCREENING (2005)

Article Biochemistry & Molecular Biology

Oligomerization of the fifth transmembrane domain from the adenosine A2A receptor

D Thévenin et al.

PROTEIN SCIENCE (2005)

Article Multidisciplinary Sciences

A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers

M Waldhoer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Pharmacology & Pharmacy

Multiple signaling states of G-protein-coupled receptors

DM Perez et al.

PHARMACOLOGICAL REVIEWS (2005)

Review Biochemistry & Molecular Biology

Methods to monitor the quaternary structure of G protein-coupled receptors

G Milligan et al.

FEBS JOURNAL (2005)

Review Multidisciplinary Sciences

Transduction of receptor signals by β-arrestins

RJ Leftowitz et al.

SCIENCE (2005)

Article Biochemistry & Molecular Biology

Agonist-independent nuclear localization of the apelin, angiotensin AT1, and bradykinin B2 receptors

DK Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

Dopamine D1 and D2 receptor co-activation generates a novel phospholipase C-mediated calcium signal

SP Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Pharmacology & Pharmacy

G protein-coupled receptor fusion proteins in drug discovery

G Milligan et al.

CURRENT PHARMACEUTICAL DESIGN (2004)

Article Pharmacology & Pharmacy

Multiple interactions between transmembrane helices generate the oligomeric α1b-adrenoceptor

JJ Carrillo et al.

MOLECULAR PHARMACOLOGY (2004)

Article Pharmacology & Pharmacy

Domain swapping in the human histamine H1 receptor

RA Bakker et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)

Article Medicine, Research & Experimental

Identification of surrogate ligands, for orphan G protein-coupled receptors

S Takeda et al.

LIFE SCIENCES (2003)

Article Biochemistry & Molecular Biology

Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins

JJ Carrillo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Oligomerization of the α1a- and α1b-adrenergic receptor subtypes -: Potential implications in receptor internalization

L Stanasila et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Properties of Arg389-β1-adrenoceptor-Gsα fusion proteins:: Comparison with Gly389-β1-adrenoceptor-Gsα fusion proteins

K Wenzel-Seifert et al.

RECEPTORS & CHANNELS (2003)

Article Biochemistry & Molecular Biology

Phosphorylation-independent desensitization of GABAB receptor by GRK4

J Perroy et al.

EMBO JOURNAL (2003)

Article Biochemistry & Molecular Biology

Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes

Y Liang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Heterodimerization of α2A- and β1-adrenergic receptors

JG Xu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Review Biochemical Research Methods

Enzyme fragment complementation: A flexible high throughput screening assay technology

RM Eglen

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2002)

Review Biotechnology & Applied Microbiology

G-protein-coupled receptor oligomerization and its potential for drug discovery

SR George et al.

NATURE REVIEWS DRUG DISCOVERY (2002)

Article Biochemistry & Molecular Biology

Identification of a novel human eicosanoid receptor coupled to Gi/o

T Hosoi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Review Biochemistry & Molecular Biology

Lipid-facing correlated mutations and dimerization in G-protein coupled receptors

PR Gouldson et al.

PROTEIN ENGINEERING (2001)

Article Biochemistry & Molecular Biology

Increased AT1 receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness

S AbdAlla et al.

NATURE MEDICINE (2001)

Review Biochemistry & Molecular Biology

Inverse, protean, and ligand-selective agonism: matters of receptor conformation

T Kenakin

FASEB JOURNAL (2001)

Article Biochemistry & Molecular Biology

Oligomerization of μ- and δ-opioid receptors -: Generation of novel functional properties

SR George et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Urology & Nephrology

Sorting proteins to their target membranes

D Brown et al.

KIDNEY INTERNATIONAL (2000)

Review Pharmacology & Pharmacy

Insights into ligand pharmacology using receptor-G-protein fusion proteins

G Milligan

TRENDS IN PHARMACOLOGICAL SCIENCES (2000)