Related references
Note: Only part of the references are listed.Challenges and opportunities with modelling and simulation in drug discovery and drug development
T. Lave et al.
XENOBIOTICA (2007)
Evaluation of physiologically based pharmacokinetic models for use in risk assessment
Weihsueh A. Chiu et al.
JOURNAL OF APPLIED TOXICOLOGY (2007)
Perchlorate and radioiodide kinetics across life stages in the human: Using PBPK models to predict dosimetry and thyroid inhibition and sensitive subpopulations based on developmental stage
Rebecca A. Clewell et al.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES (2007)
Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs
Stefan Willmann et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2007)
Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs
Graham Lappin et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2006)
Transporters as a determinant of drug clearance and tissue distribution
Y Shitara et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2006)
A novel strategy for physiologically based predictions of human pharmacokinetics
HM Jones et al.
CLINICAL PHARMACOKINETICS (2006)
Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in human plasma
FA Brightman et al.
DRUG METABOLISM AND DISPOSITION (2006)
Allometric scaling of pharmacokinetic parameters in drug discovery:: Can human CL, VSS and t1/2 be predicted from in-vivo rat data?
GW Caldwell et al.
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS (2004)
A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance
KW Ward et al.
DRUG METABOLISM AND DISPOSITION (2004)
Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry
HJ Clewell et al.
TOXICOLOGICAL SCIENCES (2004)
The evolution of molecular biology into systems biology
HV Westerhoff et al.
NATURE BIOTECHNOLOGY (2004)
Modeling of intestinal drug absorption: Roles of transporters and metabolic enzymes (for the Gillette Review Series)
KS Pang
DRUG METABOLISM AND DISPOSITION (2003)
Whole body pharmacokinetic models
I Nestorov
CLINICAL PHARMACOKINETICS (2003)
Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors
YH Zhao et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2001)
Prediction of in vivo interaction between triazolam and erythromycin based on in vitro studies using human liver microsomes and recombinant human CYP3A4
S Kanamitsu et al.
PHARMACEUTICAL RESEARCH (2000)
Share Paper
