Journal
EXPERT OPINION ON DRUG DELIVERY
Volume 11, Issue 12, Pages 1913-1922Publisher
INFORMA HEALTHCARE
DOI: 10.1517/17425247.2014.941354
Keywords
drug delivery; ferritin; MRI; nanomedicine; reporter gene
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Funding
- NCI/NIH [R00CA153772]
- Elsa U. Pardee foundation
- UGA
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Introduction: Due to unique architecture and surface properties, ferritin has emerged as an important class of biomaterial. Many studies suggest that ferritin and its derivatives hold great potential in a wide range of bio-applications. Areas covered: In this review, we summarize recent progress on employing ferritins as a platform to construct functional nanoparticles for applications in MRI, optical imaging, cell tracking, and drug delivery. Expert opinion: As a natural polymer, ferritins afford advantages such as high biocompatibility, good biodegradability, and a relatively long plasma half-life. These attributes put ferritins ahead of conventional materials in clinical translation for imaging and drug delivery purposes.
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