Journal
EXPERT OPINION ON DRUG DELIVERY
Volume 6, Issue 4, Pages 405-420Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425240902824808
Keywords
antiviral agents; oral bioavailability; prodrugs; pronucleotides
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Funding
- NIH [U01 A1061457, R44 A1056864]
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Nucleotide analogues have been well accepted as therapeutic agents active against a number of viruses. However, their use as antiviral agents is limited by the need for phosphorylation by endogenous enzymes, and if the analogue is orally administered, by low bioavailability due to the presence of an ionizable diacid group. To circumvent these limitations, a number of prodrug approaches have been proposed. The ideal prodrug achieves delivery of a parent drug by attachment of a non-toxic moiety that is stable during transport and delivery, but is readily cleaved to release the parent drug once at the target. Here, a brief overview of several promising prodrug strategies currently under development is given.
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