Journal
EXPERT OPINION ON DRUG DELIVERY
Volume 5, Issue 11, Pages 1173-1184Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/17425240802431811
Keywords
controlled release; growth factor delivery; heparin; heparin-binding growth factor (HBGF); polymeric particulate; tissue regeneration
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Funding
- Ministry of Health & Welfare, Republic of Korea [02-PJ3-PG6-EV11-0002]
- Ministry of Science & Technology, Republic of Korea [13020214]
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The strategy of growth factor delivery to specific sites for therapeutic applications has been considered an essential process in biomedical fields despite some obstacles, such as a non-controlled release with initial burst. This article focuses on particulate systems using heparin for the controlled delivery of heparin-binding growth factors (HBGFs), an emerging area in the tissue engineering field. Since heparin has been widely utilized for growth factor delivery due to its electrostatic nature and specific affinity with HBGFs, heparin-containing polymeric particulates can be utilized as functional carriers to deliver growth factors in a controlled manner. In particular, examples of the HBGF delivery systems containing heparin, perspectives and potential applications are described and discussed.
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