Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 14, Issue 1, Pages 11-14Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.2013.844227
Keywords
antibiotics; antimicrobial peptides; drug-resistant bacteria; peptide design
Funding
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK072506] Funding Source: NIH RePORTER
- NCATS NIH HHS [UL1 TR000005] Funding Source: Medline
- NIDDK NIH HHS [P30 DK072506] Funding Source: Medline
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Antibiotics have been among the most successful classes of therapeutics and have enabled many of modern medicine's greatest advances. However, antibiotic-resistant bacteria are emerging as critical public health threats, with recent accounts of bacterial strains resistant to all approved antibiotics. Antimicrobial peptides (AMPs) are naturally occurring molecules with the potential to serve as the basis for a new class of anti-infectives targeting these difficult-to-treat bacteria. The unique activities and features of AMPs are discussed, with a focus toward the clinical importance of priming the antibiotic pipeline and the role AMPs can fulfill in the future of fighting drug-resistant bacteria.
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