Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 12, Issue 11, Pages 1495-1504Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.2012.712107
Keywords
cancer therapy; cell death; cell survival; RNAi
Funding
- National Natural Sciences Foundation of China [81072146]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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Introduction: This review presents the intriguing success of RNA interference (RNAi)-mediated gene silencing and its advantages and obstacles in cancer therapy. Areas covered: RNAi has implications in metabolic disease, viral hepatitis, cardiovascular and cerebrovascular diseases, HIV, neurodegenerative disorders and cancer. RNAi can enhance the specificity and efficacy of therapeutic intervention for human diseases while at the same time reducing toxicity. The existing research related to gene therapy suggests encouraging prospects of a new high-efficiency and low-toxicity anti-tumor therapy. Although gene therapy is still in the experimental research phase, in the near future, this method will become an important means for the treatment of cancer therapies and it will be widely used in clinical practice. Expert opinion: RNAi-based drug development is still in preclinical trial and several challenges limit the use of RNAi in the clinic. It is believed that further investigation of the mechanisms of RNAi-based therapies will help overcome these limitations and provide powerful weapons in the oncology clinic.
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