Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 12, Issue 11, Pages 1423-1425Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.2012.711310
Keywords
cancer; FoxP3; Helios; iTregs; nTregs
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Recent work debates the suitability of Helios, an Ikarios family transcription factor, as a marker of thymic-derived natural T regulatory cells. However, Helios expression could be of particular importance in cancer. We and others reported that the majority of peripheral and tumour-infiltrating FoxP3(+) Tregs expresses Helios. Additionally, recent observations indicate that FoxP3(+) Helios(+) Tregs possess more suppressive characteristics, as compared to FoxP3(+) Helios(-) Tregs.
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