Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 11, Issue 3, Pages 359-374Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.2011.548800
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Funding
- Jesse's Journey Foundation for Gene and Cell Therapy of Canada
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Areas covered: Among the two routes used to deliver cells to skeletal muscles, that is intramuscular and intravascular, this paper focuses on the intramuscular route due to our expertise and because it is the most used in animal experiments and the only tested so far in humans. Given the absence of recent reviews about clinical observations and the profusion based on mouse results, this review prioritizes observations made in humans and non-human primates. The review provides a vision of cell transplantation in myology centered on what can be learned from clinical trials and from preclinical studies in non-human primates and leading mouse studies. Expert opinion: Experiments on myogenic cell transplantation in mice are essential to quickly identify potential treatments, but studies showing the possibility to scale up the methods in large mammals are indispensable to determine their applicability in humans and to design clinical protocols.
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