Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 11, Issue 5, Pages 641-653Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.2011.562495
Keywords
adjuvants; children; influenza; influenza vaccines; prevention; vaccination
Funding
- Italian Ministry of Health
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Introduction: Pediatric influenza not only leads to significant rates of morbidity and an increased risk of hospitalisation, it can also have a substantial socioeconomic impact because children shed larger amounts of viruses over longer periods than adults. This makes adequate prevention desirable, and the best means of reducing the incidence and risks of infection in children is influenza vaccination. Areas covered: The main aim of this review is to analyse the characteristics of new means of influenza prevention and identify which may be important in pediatrics. An updated overview of influenza vaccines is provided, concentrating on strategies of inducing immunogenicity and facilitating the administration of both old and new vaccines. Expert opinion: The currently available data clearly indicate that influenza in children is much less optimally prevented than other vaccine-preventable diseases. A number of different approaches seem to be promising in adults, but there is an urgent need for new strategies when using old vaccines in children or testing new vaccines in pediatric trials.
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