Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 10, Issue 5, Pages 701-709Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712591003769816
Keywords
bone marrow; immunosuppression; mesenchymal stem cells; stem cell transplantation; systemic lupus erythematosus
Funding
- Chinese National Natural Science Foundation [30772014, 30972736]
- Chinese National 115 Supporting Program [2008BAI59B02]
- Jiangsu Province 135 Talent Foundation [RC2007002]
- Jiangsu Province Natural Science Foundation [09KJB320010]
- Nanjing public health bureau [ZKX09025]
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Importance of the field: Bone-marrow-derived mesenchymal stem cells (BMMSC) are multipotent non-hematopoietic progenitor cells that are being explored as a promising new treatment for tissue regeneration. Although their immunomodulatory properties are not yet completely understood, their low immunogenic potential together with their effects on immune response make them a promising therapeutic tool for severe refractory autoimmune diseases including systemic lupus erythematosus (SLE). Area covered in this review: Our aim is to discuss recent progress in understanding the role of malfunctioning BMMSC in etiopathogenesis of SLE and to explore allogenic BMMSC transplantation as a potential therapy for SLE. What the reader will gain: Recent evidence suggests that the functions of BMMSC are disrupted in SLE pathology. This malfunction may result as a corollary of the disease, or may play a more fundamental role in its etiopathogenesis. We provide a brief characterization of BMMSC immunomodulatory effects, and describe our current understanding of the mechanisms by which it plays a part in treating SLE. We also present our clinical trial using allogenic BMMSC in this context. Take home message: Allogenic BMMSC appear to be a safe therapeutic option for treatment-resistant SLE as illustrated in our clinical trial.
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