Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 10, Issue 10, Pages 1441-1451Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.2010.517191
Keywords
mesenchymal stem cells (MSCs); pericytes; perivascular cells; perivascular niche
Funding
- Medical research Council (MRC)
- Wellcome Trust
- Department of Health via the National Institute for Health Research (NIHR)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- MRC [G0600041] Funding Source: UKRI
- Medical Research Council [G0600041] Funding Source: researchfish
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Importance of the field: Mesenchymal stem cells are multipotent adult stem cell populations that have broad differentiation plasticity and immunosuppressive potential that render them of great importance in cell-based therapies. They are identified by in vitro characteristics based on their differentiation potential for clinical approaches while their biological properties and in vivo identities are often less understood. Areas covered in this review: Recent research carried out in the last decade on mesenchymal stem cell biology suggests that mesenchymal stem cells from various tissues reside in a perivascular location and these can be identified as pericytes that function as mural cells in microvessels. What the reader will gain: This review covers recent progress on understanding the link between pericytes and mesenchymal stem cells discussing specific points such as response to injury and tissue-specific functions. Take home message: Despite a long and controversial history, there is a growing acceptance that perivascular cells are connected with mesenchymal stem cells, all that is really lacking is genetic evidence to show differentiation of pericytes into different cells types.
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