Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 10, Issue 7, Pages 1121-1130Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.2010.493872
Keywords
Alzheimer's disease; amyloid-beta; beta-amyloid peptide; bapineuzumab; immunization; immunotherapy; monoclonal antibody; vasogenic edema
Funding
- Larry L. Hillblom Foundation
- NIH [K23NS48855, R01AG031278]
- John Douglas French Foundation
- Hellman foundation
- Elan
- Genentech
- Janssen
- Merck
- Novartis
- Pfizer
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Importance of the field: Alzheimer's disease is the leading cause of dementia in the elderly, and there is no disease-modifying therapy yet available. Immunotherapy directed against the beta-amyloid peptide may be capable of slowing the rate of disease progression. Bapineuzumab, an anti-beta-amyloid monoclonal antibody, will be the first such agent to emerge from Phase III clinical trials. Areas covered in this review: The primary literature on bapineuzumab from 2009 and 2010 is reviewed in its entirety, along with the literature on AN1792, a first-generation anti-beta-amyloid vaccine, from 2003 to 2009. Other Alzheimer's disease immunotherapeutics currently in development, according to www.clinicaltrials.gov, are also discussed. What the reader will gain: In addition to a critical appraisal of the Phase II trial results for bapineuzumab, this review considers the broader field of immunotherapy for Alzheimer's disease as a whole, including the challenges ahead. Take home message: Bapineuzumab appears capable of reducing the cerebral b-amyloid peptide burden in patients with Alzheimer's disease. However, particularly in APOE e4 carriers, its ability to slow disease progression remains uncertain, and vasogenic edema - a dose-limiting and potentially severe adverse reaction - may limit its clinical applicability.
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