Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 10, Issue 9, Pages 1315-1329Publisher
INFORMA HEALTHCARE
DOI: 10.1517/14712598.2010.504705
Keywords
hematopoietic stem cell; self-renewal; stroma; Wnt
Funding
- Ministry of Health and Welfare [0405-DB01-0104-0006]
- Korea Science and Engineering Foundation (KOSEF), Republic of Korea [2008-05981]
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Importance of the field: Microenvironment has emerged as crucial element in the regulation of hematopoietic stem cells (HSCs) in the stem cell niche. Recent studies have demonstrated that Wnt/beta-catenin signals are clearly involved in the stem cell niche, raising the possibility that the hematopoietic microenvironment is a potential target for stem cell therapy. Areas covered in this review: In this review, the biological outcomes of Wnt/beta-catenin signals on HSC activity are summarized in various study models and potential reasons for discrepancies are discussed. Evidence for the microenvironmental targeting of Wnt/beta-catenin signals and studies that verify this concept is summarized. What the reader will gain: We show that distinct effects of Wnt/beta-catenin on HSCs can be caused depending on their target of activation in the hematopoietic microenvironment. We show stromal targeting of Wnt/beta-catenin signals and cross-talk with notch signals in the niche during bone marrow regeneration enhancing the self-renewal of HSCs. Take home message: The identification of stroma-mediated Wnt/beta-catenin effects now allows the integration of discrepancies in previously reported findings and suggests that the stromal targeting of wnt/beta-catenin signals could serve as a potential therapeutic strategy for activating a stem cell niche for the efficient regeneration of HSCs.
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