Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 9, Issue 9, Pages 1199-1206Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712590903110709
Keywords
acneiform rash; EGFR; h-r3; monoclonal antibody; nimotuzumab; targeted therapy
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Due to the broad importance of EGFR to tumorogenesis, targeted therapy against it has rapidly developed into a novel paradigm for cancer treatment. Two promising classes of drugs are now in use and undergoing development that target this receptor: tyrosine kinase inhibitors (TKIs) and mAbs that inhibit EGFR's extracellular domain. Nimotuzumab, a humanized murine mAb created in Cuba, has demonstrated antitumor activity similar to that of other anti-EGFR mAbs and shows promise as a single agent and as an adjunct to radiation in Phase I and II clinical trials. Surprisingly, the typical severe dermatological toxicities thus far associated with anti-EGFR therapy have not been described with nimotuzumab. Here we summarize the background, development and characteristics of this new drug while reviewing the latest preclinical and clinical trial data that underpin its gradual adoption into clinical practice.
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