Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 8, Issue 6, Pages 799-804Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.8.6.799
Keywords
autoimmune disorder; efficacy; IGIV; immunodeficiency; immunoglobulin; IVIG; liquid; safety
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Background: Even though all immunoglobulin intravenous (IGIV) end products have high IgG concentrations, variations in manufacturing processes lead to unique product characteristics. Objective: Solvent/detergent-treated IGIV (IGIV-S/D) liquid 10% (Gammagard(R) or Kiovig(R) liquid) is one of the newer products, and this article will discuss and compare its efficacy, safety, tolerability and effect on patient care. Methods: The search terms 'immunoglobulin,' 'IGIV,' 'IVIG,' and 'liquid' were entered into PubMed/Medline and Google for the literature search in preparation of this manuscript. Additional references were screened from researched literature. Results/conclusion: Gammagard liquid 10% has shown significant activity in primary immunodeficiency and immune thrombocytopenic purpura. It is a sugar- and sodium-free product with improved safety, tolerability and convenience. Overall, Gammagard liquid is a valuable addition to available therapies that has utility in life-threatening and complicated diseases, and its use will continue to grow.
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