Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 8, Issue 7, Pages 993-1001Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.8.7.993
Keywords
cancer; chemotherapy; filgrastim; G-CSF; neutropenia; pegfilgrastim
Ask authors/readers for more resources
Background: Currently G-CSFs such as filgrastim (Neupogen (R), Amgen, Inc.) and pegfilgrastim (Neulasta (R), Amgen, Inc.) are widely used to reduce chemotherapy-induced neutropenia. Pegfilgrastim is a novel recombinant human G-CSF and its unique neutrophil-mediated clearance allows it to be administered once per chemotherapy cycle. Objective: To address the pharmacology of pegfilgrastim and provide an overview of its current clinical use in cancer chemotherapy. Methods: Review and summary of publications on pegfilgrastim indexed in the PubMed electronic database. Results/conclusion: The efficacy of pegfilgrastim is similar to or greater than that of filgrastim and an important advantage of pegfilgrastim is its schedule of administration that may be associated with greater treatment compliance and improved patient quality of life. Ongoing clinical trials continue to explore further potential uses for pegfilgrastim.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available