Journal
EXPERIMENTAL PHYSIOLOGY
Volume 93, Issue 9, Pages 1085-1090Publisher
WILEY
DOI: 10.1113/expphysiol.2008.042267
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Funding
- NIA NIH HHS [AG-17474, AG-15389, R01 AG015389, AG-18408, T32 AG000268, R01 AG015389-02, AG-00268, P60 AG12583, R01 AG017474-01A1, R01 AG017474, R01 AG018408, P60 AG012583] Funding Source: Medline
- NIDDK NIH HHS [DK-46204, P30 DK046204] Funding Source: Medline
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The lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) expressed on vascular cells plays a major role in atherogenesis by internalizing and degrading oxidized low-density lipoprotein. LOX-1 can be cleaved from the cell surface and released as soluble LOX-1 (sLOX-1), and elevated sLOX-1 levels may be indicative of atherosclerotic plaque instability. We examined associations between the LOX-1 gene 3'UTR-C/T and G501C polymorphisms and plasma sLOX-1 levels in 97 healthy older men and women. The frequencies for the 3'UTR-T and 501C alleles were 46 and 10%, respectively. Plasma sLOX-1 levels were significantly higher in the 3'UTR CC genotype group compared with both the CT (P = 0.02) and TT genotype groups (P = 0.002). Plasma sLOX-1 levels were also significantly higher in the 501GC genotype group compared with the GG genotype group (P = 0.004). In univariate analyses, sLOX-1 levels were significantly associated with both the 3'UTR-C/T and G501C polymorphisms. These associations remained significant after adjusting for age, sex, race and body mass index. In conclusion, variation in the LOX-1 gene is associated with plasma sLOX-1 levels in older men and women.
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