Journal
EXPERIMENTAL PARASITOLOGY
Volume 135, Issue 1, Pages 1-8Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2013.05.011
Keywords
Caenorhabditis elegans; Albendazole; Ultrastructure
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Funding
- NHI National Center for Research Resources
- Fundacao de Coordenacao de aperfeicoamento de Pessoal de Nivel Superior-CAPES
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq
- Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro-FAPERJ
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This study investigated the effects of albendazole on the viability, morphology and ultrastructure of different life stages of Caenorhabditis elegans. The albendazole EC50 value after seven days of treatment was 18.43 mu M. This concentration was very efficient against all the stages. Light and electron microscopy analysis showed damage to the body wall of the adults and larvae. An intense desquamation of the cuticle of larvae and of the surface of the eggs was observed, preventing their hatching and development. The main ultrastructural damage detected was the degeneration of the mitochondria in the noncontractile muscle of the body wall, which appeared as large vacuoles. This study reaffirmed the use of C elegans as a screening system for compounds with potential anthelmintic activity and showed the effects of albendazole on the different life stages of these worms. (C) 2013 Elsevier Inc. All rights reserved.
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