Journal
EXPERIMENTAL PARASITOLOGY
Volume 132, Issue 1, Pages 14-21Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2011.05.005
Keywords
Trematode; Schistosoma mansoni; Eggs; C-Type lectins; Glycosylation; Immunomodulation
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Schistosome eggs and egg-derived molecules are potent immunomodulatory agents. There is increasing evidence that the interplay between egg glycoproteins and host C-type lectins plays an important role in shaping immune responses during schistosomiasis. As most experiments in this field so far have been performed using complex protein/glycoprotein mixtures or synthetic model glycoconjugates, it is still largely unclear which individual moieties of schistosome eggs are immunologically active. In this review we will discuss molecular aspects of Schistosoma mansoni egg glycoproteins, their interactions with C-type lectins, and the relevance to schistosome egg immunobiology. (c) 2011 Elsevier Inc. All rights reserved.
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