4.2 Article

Toxoplasma gondii: Myenteric neurons of intraperitoneally inoculated rats show quantitative and morphometric alterations

Journal

EXPERIMENTAL PARASITOLOGY
Volume 129, Issue 1, Pages 5-10

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2011.06.008

Keywords

Toxoplasmosis; Enteric Nervous System; Gut; Myenteric plexus; Infection; Inflammation

Categories

Funding

  1. Universidade Paranaense - UNIPAR, Brazil

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Several studies have demonstrated that the myenteric plexus experiences quantitative and morphometric changes in rats inoculated orally with Toxoplasma gondii. This paper aims to verify if these alterations are also seen when the same animals are inoculated intraperitoneally with the parasite. In order to do wthat, six Wistar rats (Rattus norvegicus) 60 days of age were infected intraperitoneally with 10(6) tachyzoites of a genotype IT. gondii strain (BTU IV). After 60 days, the animals were anaesthetised and underwent laparotomy. All organs from the small and large intestines were removed, measured, dissected and underwent whole-mount Giemsa technique to stain the neurons in the myenteric plexus. A quantitative and morphometric analysis of these cells was made, and it showed that the parasite causes the death of myenteric neurons in the jejunum and morphometric alterations in these cells throughout the intestine. However, the cellular response of myenteric neurons to T. gondii is heterogeneous compared the different organs from the gut. (C) 2011 Elsevier Inc. All rights reserved.

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