Journal
EXPERIMENTAL PARASITOLOGY
Volume 126, Issue 3, Pages 304-309Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2010.05.022
Keywords
Cryptosporidium parvum; Apicomplexa; Immune response
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Funding
- German Research Foundation [DFG-SFB490-D7]
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Species of the genus Cryptosporidium are protozoan parasites (Apicomplexa) that cause gastroenteritis in animals and humans. Of these Ctyptosporidium parvum and Cryptosporidium hominis are the major causative agents of human cryptosporidiosis. Whereas infection is self-limiting in the immunocompetent hosts, immunocompromised individuals develop a chronic, life-threatening disease. As specific therapeutic or preventive interventions are not yet available, better understanding of the immune response to the parasite is required. This minireview briefly summarizes the factors involved in the innate and acquired immune response in this pathogen-host interaction with an emphasis on more recent data from mouse models of infection. (C) 2010 Elsevier Inc. All rights reserved.
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