Journal
EXPERIMENTAL PARASITOLOGY
Volume 124, Issue 4, Pages 403-408Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2009.12.010
Keywords
Trichinella spiralis; Recombinant paramyosin (rTs-Pmy); Montanide ISA206; Montanide ISA720
Categories
Funding
- National Natural Science Foundation of China [30872201]
- Natural Science Foundation of Beijing [5092006]
- National Science & Technology Major Project [2008ZX10004-011]
- Beijing Municipal Science & Technology Commission [Z080502036708012]
- Research & Development Fund of the Municipal Education Commission of Beijing [kz200810025009]
- Beijing Municipal project for Developing Advanced Human Resources for Education (BAHED)
- PHR [PHR200907112]
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Our previous studies showed that immunization with recombinant paramyosin from Trichinella spiralis (rTs-Pmy) formulated with Freund's adjuvant significantly reduced larval burden in mice after T. spiralis larval challenge. Since Freund's adjuvant is toxic and not a suitable adjuvant for clinical vaccine trials, we evaluated the ability of the adjuvants Montanide ISA206 and ISA720 to stimulate immune responses during rTs-Pmy immunization and to enhance protective immunity. The results revealed that immunization of BALB/c mice with rTs-Pmy formulated with either ISA206 or ISA720 triggered Th1 and Th2 immune responses similar to those produced by the conventional Freund's adjuvant formulation and also provided a similar level of protection against T spiralis larval challenge. This indicates that the recombinant Ts-Pmy formulated with Montanide ISA206 or ISA720 may be an effective and safety vaccine strategy for trichinellosis. (C) 2010 Elsevier Inc. All rights reserved.
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