Journal
EXPERIMENTAL PARASITOLOGY
Volume 126, Issue 1, Pages 91-96Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2009.11.016
Keywords
Acanthamoeba; Drug targets; Drug validation
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Funding
- William Ross Foundation for the Prevention of Blindness
- University of Strathclyde
- University of the West of Scotland
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New more efficacious antimicrobials as required for the treatment of Acanthamoeba infections as those currently available require arduous treatment regimes, are not always effective and are poorly active against the cystic stages. Herein, we review potential drug targets including tubulin, alternative oxidase, amino acid biosynthesis and myosin. In addition, we review the literature for current missing tools and resources for the identification, validation and development of new antimicrobials for this organism. Additional targets should come to light through a concerted genome sequencing effort. (C) 2010 Published by Elsevier Inc.
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